Cat. No. 1708
Chemical Name: 1-(4-Chlorobenzoyl)-5-methoxy-2-met
Biological ActivityCyclooxgenase (COX) inhibitor; displays selectivity for COX-1 (IC50 values are 230 and 630 nM for human COX-1 and COX-2 respectively). Widely used anti-inflammatory agent.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Walters and Willoughby (1965) Indomethacin, a new anti-inflammatory drug: its potential use as a laboratory tool. J.Pathol.Bacteriol. 90 641. PMID: 5849618.
Shen and Winter (1977) Chemical and biological studies on indomethacin, sulindac and their analogs. Adv.Drug Res. 12 90. PMID: 343530.
Palomer et al (2002) Identification of novel cyclooxygenase-2 selective inhibitors using pharmacophore models. J.Med.Chem. 45 1402. PMID: 11906281.
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Keywords: Indomethacin, supplier, Cyclooxygenase, inhibitors, COX-1, COX-2, Oxygenases, Oxidases
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April 12 - 15, 2015