R&D Systems Inc. Tocris Bioscience Boston Biochem

Indomethacin

Cat. No. 1708

Indomethacin C19H16ClNO4 [53-86-1]

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Chemical Name: 1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole

Biological Activity

Cyclooxgenase (COX) inhibitor; displays selectivity for COX-1 (IC50 values are 230 and 630 nM for human COX-1 and COX-2 respectively). Widely used anti-inflammatory agent.

Technical Data

M.Wt:
357.79
Formula:
C19H16ClNO4
Solubility:
Soluble to 50 mM in ethanol with gentle warming and to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at RT
CAS No:
53-86-1

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Walters and Willoughby (1965) Indomethacin, a new anti-inflammatory drug: its potential use as a laboratory tool. J.Pathol.Bacteriol. 90 641. PMID: 5849618.

Shen and Winter (1977) Chemical and biological studies on indomethacin, sulindac and their analogs. Adv.Drug Res. 12 90. PMID: 343530.

Palomer et al (2002) Identification of novel cyclooxygenase-2 selective inhibitors using pharmacophore models. J.Med.Chem. 45 1402. PMID: 11906281.

If you know of a relevant citation for this product please let us know.

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Keywords: Indomethacin, supplier, Cyclooxygenase, inhibitors, COX-1, COX-2, Oxygenases, Oxidases

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