Cat. No. 1708

Indomethacin C19H16ClNO4 [53-86-1]

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Chemical Name: 1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole

Biological Activity

Cyclooxgenase (COX) inhibitor; displays selectivity for COX-1 (IC50 values are 230 and 630 nM for human COX-1 and COX-2 respectively). Widely used anti-inflammatory agent.

Technical Data

Soluble to 50 mM in ethanol with gentle warming and to 100 mM in DMSO
>99 %
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet


Walters and Willoughby (1965) Indomethacin, a new anti-inflammatory drug: its potential use as a laboratory tool. J.Pathol.Bacteriol. 90 641. PMID: 5849618.

Shen and Winter (1977) Chemical and biological studies on indomethacin, sulindac and their analogs. Adv.Drug Res. 12 90. PMID: 343530.

Palomer et al (2002) Identification of novel cyclooxygenase-2 selective inhibitors using pharmacophore models. J.Med.Chem. 45 1402. PMID: 11906281.

If you know of a relevant citation for this product please let us know.

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Keywords: Indomethacin, supplier, Cyclooxygenase, inhibitors, COX-1, COX-2, Oxygenases, Oxidases, Cyclooxygenase Inhibitors

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