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BIIE 0246

Cat. No. 1700

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Chemical Name: N-[(1S)-4-[(Aminoiminomethyl)amino]-1-[[[2-(3,5-dioxo-1,2-diphenyl-1,2,4-triazolidin-4-yl)ethyl]amino]carbonyl]butyl]-1-[2-[4-(6,11-dihydro-6-oxo-5H-dibenz[b,e]azepin-11-yl)-1-piperazinyl]-2-oxoethyl]-cyclopentaneacetamide

Biological Activity

Potent, selective and competitive non-peptide antagonist for the neuropeptide Y Y₂ receptor (IC₅₀ = 15 nM). Displays > 650-fold selectivity over Y₁, Y₄ and Y₅ receptors. Active in vivo.

Technical Data

M.Wt:

896.06

Formula:

C₄₉H₅₇N₁₁O₆

Solubility:

Soluble to 25 mM in ethanol and to 75 mM in DMSO

Purity:

>98 %

Storage:

Store at +4°C

CAS No:

246146-55-4

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Doods et al (1999) BIIE0246: a selective and high affinity neuropeptide Y Y₂ receptor antagonist. Eur.J.Pharmacol. 384 R3. PMID: 10611450.

Dumont et al (2000) BIIE0246, a potent and highly selective non-peptide neuropeptide Y Y₂ receptor antagonist. Br.J.Pharmacol. 129 1075. PMID: 10725255.

Malmstrom (2001) Vascular pharmacology of BIIE0246, the first selective non-peptide neuropeptide Y Y₂ receptor antagonist, in vivo. Br.J.Pharmacol. 133 1073. PMID: 11487518.

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Keywords: BIIE 0246, supplier, Potent, selective, non-peptide, NPY, Y2, antagonists, Neuropeptide, Y, Receptors, BIIE0246, neuropeptides

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