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FK 3311Cat. No. 2776 |
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Chemical Name: N-[4-Acetyl-2-(2,4-difluorophenoxy)phenyl]methanesulfonamide |
Biological Activity
Cyclooxygenase-2 (COX-2) inhibitor. Inhibits zymosan-induced prostaglandin E2 production by rat peritoneal neutrophils in vitro and adjuvant-induced arthritis in vivo. Anti-inflammatory.Certificate of Analysis / Safety Data Sheet
References
Tsuji et al (1992) Studies on antiinflammatory agents. I. Synthesis and pharmacological properties of 2'-phenoxy-methanesulfonanilide derivatives. Chem.Pharm.Bull. 40 2399. PMID: 1446362.
Nakamura et al (1993) Studies on antiinflammatory agents. III. Synthesis and pharmacological properties of metabolites of 4'-acetyl-2'-(2,4-difluorophenoxy)methanesulfonanilide (FK3311). Chem.Pharm.Bull. 41 (2050).
Otani et al (2007) Effects of the COX-2 inhibitor FK3311 on ischemia-reperfusion injury in the rat lung. J.Invest.Surg. 20 175. PMID: 17613692.
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Keywords: FK 3311, supplier, Cyclooxygenase-2, COX-2, inhibitors, Oxygenases, Oxidases, FK3311
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