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RU 28318, potassium salt

Cat. No. 1672

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Alternative Name: Oxprenoate potassium

Chemical Name: (7α,17α)-17-Hydroxy-3-oxo-7-propylpregn-4-ene-21-carboxylic acid, potassium salt

Biological Activity

Potent and selective antagonist for the mineralocorticoid receptor (MR). Inhibits aldosterone production and secretion, and selectively decreases ex-vivo MR binding in the hippocampus of adrenalectomised rats. Also decreases blood pressure in female rats following central administration in vivo.

Technical Data

M.Wt:

440.66

Formula:

C₂₅H₃₇O₄K

Solubility:

Soluble to 100 mM in water

Purity:

>99 %

Storage:

Desiccate at +4°C

CAS No:

76676-34-1

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Perroteau et al (1984) The effect of the antimineralocorticoid RU 28318 on aldosterone biosythesis in vitro. J.Steroid Biochem. 20 853. PMID: 6323881.

Kim et al (1998) Evaluation of RU28318 and RU40555 as selective mineralocorticoid receptor and glucocorticoid receptor antagonists, respectively: receptor measures and functional studies. J.Steroid Biochem.Mol.Biol. 67 213. PMID: 9879980.

Rahmouni et al (1999) Cardiovascular and renal effects of central administration of a mineralocorticoid receptor antagonist in concious female rats. Eur.J.Pharmacol. 385 199. PMID: 10607876.

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