RU 28318, potassium salt
Cat. No. 1672
Alternative Name: Oxprenoate potassium
Chemical Name: (7α,17α)-17-Hydroxy-3-oxo-7-propylpre
Biological ActivityPotent and selective antagonist for the mineralocorticoid receptor (MR). Inhibits aldosterone production and secretion, and selectively decreases ex-vivo MR binding in the hippocampus of adrenalectomised rats. Also decreases blood pressure in female rats following central administration in vivo.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Perroteau et al (1984) The effect of the antimineralocorticoid RU 28318 on aldosterone biosythesis in vitro. J.Steroid Biochem. 20 853. PMID: 6323881.
Kim et al (1998) Evaluation of RU28318 and RU40555 as selective mineralocorticoid receptor and glucocorticoid receptor antagonists, respectively: receptor measures and functional studies. J.Steroid Biochem.Mol.Biol. 67 213. PMID: 9879980.
Rahmouni et al (1999) Cardiovascular and renal effects of central administration of a mineralocorticoid receptor antagonist in concious female rats. Eur.J.Pharmacol. 385 199. PMID: 10607876.
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Keywords: RU 28318, potassium salt, supplier, Potent, selective, mineralocorticoid, antagonists, Aldosterone, Receptors, RU28318, potassium, salt
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