RU 28318, potassium salt

Cat. No. 1672

RU 28318, potassium salt C25H37O4K [76676-34-1]

Price and Availability

For RU 28318, potassium salt pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Alternative Name: Oxprenoate potassium

Chemical Name: (7α,17α)-17-Hydroxy-3-oxo-7-propylpregn-4-ene-21-carboxylic acid, potassium salt

Biological Activity

Potent and selective antagonist for the mineralocorticoid receptor (MR). Inhibits aldosterone production and secretion, and selectively decreases ex-vivo MR binding in the hippocampus of adrenalectomised rats. Also decreases blood pressure in female rats following central administration in vivo.

Technical Data

M.Wt:
440.66
Formula:
C25H37O4K
Solubility:
Soluble to 100 mM in water
Purity:
>98 %
Storage:
Desiccate at +4°C
CAS No:
76676-34-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Perroteau et al (1984) The effect of the antimineralocorticoid RU 28318 on aldosterone biosythesis in vitro. J.Steroid Biochem. 20 853. PMID: 6323881.

Kim et al (1998) Evaluation of RU28318 and RU40555 as selective mineralocorticoid receptor and glucocorticoid receptor antagonists, respectively: receptor measures and functional studies. J.Steroid Biochem.Mol.Biol. 67 213. PMID: 9879980.

Rahmouni et al (1999) Cardiovascular and renal effects of central administration of a mineralocorticoid receptor antagonist in concious female rats. Eur.J.Pharmacol. 385 199. PMID: 10607876.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

View Related Products by Product Action

Keywords: RU 28318, potassium salt, supplier, Potent, selective, mineralocorticoid, antagonists, Aldosterone, Receptors, RU28318, potassium, salt, Tocris Bioscience, Mineralocorticoid Receptor Antagonists

Quick Order

Find multiple products by catalog number

divider line

Cancer Research Product Guide

Cancer Research Product Guide

Highlights over 750 products for cancer research. Request copy or view PDF today.

divider line

Nuclear Receptors Product Listing

Nuclear Receptors Product Listing

Highlights over 150 products for nuclear receptors. Request copy or view PDF today.

divider line

Cardiovascular Research Product Guide

Cardiovascular Research Product Guide

Highlights over 250 products for cardiovascular research. Request copy or view PDF today.

divider line

New Products in this Area

DY 268

Potent FXR antagonist

Cytosporone B

High affinity Nur77 agonist

Liothyronine sodium

Thyroid hormone (T3) analog; also promotes adipogenic differentiation of MSCs

CINPA 1

Potent CAR antagonist

Sign-up for new product e-alerts
divider line

AAI 2016

Win a $1,000 travel grant

AAI Travel Grant

Bio-Techne is offering 10 travel grants of $1,000 for AAI 2016.