Cat. No. 1646
Alternative Name: AF 1890
Chemical Name: 1-[(2,4-Dichlorophenyl)methyl]-1H-i
Biological ActivityAnticancer and antispermatogenic agent in vitro and in vivo. Inhibits cellular energy metabolism in some cells via inhibition of mitochondrial hexokinase. Also blocks CFTR Cl- channels in vitro.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Lobl et al (1981) Effects of lonidamine (AF 1890) and its analogues on follicle-stimulating hormone, luteinizing hormone, testosterone and rat androgen binding protein concentrations in the rat and rhesus monkey. Chemotherapy 27 61. PMID: 6793318.
De Martino et al (1984) Effects of lonidamine on murine and human tumor cells in vitro. A morphological and biochemical study. Oncology 41 15. PMID: 6717891.
Teiche (1994) Lonidamine: in vitro/in vivo correlations. Eur.J.Cancer 30A 1411. PMID: 7833093.
Gong et al (2002) Mechanism of lonidamine inhibition of the CFTR chloride channel. Br.J.Pharmacol. 137 928. PMID: 12411425.
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Keywords: Lonidamine, supplier, Mitochondrial, hexokinase, inhibitors, CFTR, Cl-, chloride, channels, blockers, Carbohydrate, Metabolism, Kinases, AF1890, Tocris Bioscience, Hexokinase Inhibitors
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