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LonidamineCat. No. 1646 |
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Alternative Name: AF 1890 Chemical Name: 1-[(2,4-Dichlorophenyl)methyl]-1H-indazole-3-carboxylic acid |
Biological Activity
Anticancer and antispermatogenic agent in vitro and in vivo. Inhibits cellular energy metabolism in some cells via inhibition of mitochondrial hexokinase. Also blocks CFTR Cl- channels in vitro.Certificate of Analysis / Safety Data Sheet
References
Lobl et al (1981) Effects of lonidamine (AF 1890) and its analogues on follicle-stimulating hormone, luteinizing hormone, testosterone and rat androgen binding protein concentrations in the rat and rhesus monkey. Chemotherapy 27 61. PMID: 6793318.
De Martino et al (1984) Effects of lonidamine on murine and human tumor cells in vitro. A morphological and biochemical study. Oncology 41 15. PMID: 6717891.
Teiche (1994) Lonidamine: in vitro/in vivo correlations. Eur.J.Cancer 30A 1411. PMID: 7833093.
Gong et al (2002) Mechanism of lonidamine inhibition of the CFTR chloride channel. Br.J.Pharmacol. 137 928. PMID: 12411425.
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Keywords: Lonidamine, supplier, Mitochondrial, hexokinase, inhibitors, CFTR, Cl-, chloride, channels, blockers, Carbohydrate, Metabolism, Kinases, AF1890
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