8CPT-2Me-cAMP, sodium salt
Cat. No. 1645
Chemical Name: 8-(4-Chlorophenylthio)-2'-O-methyladenosine-3',5'-cyclic monophosphate sodium salt
Biological ActivitySelective activator of Epac, the cAMP-sensitive guanine nucleotide-exchange factor for Rap1 and Rap2. Activates Epac1 (EC50 = 2.2 μM), but not PKA (EC50 > 10 μM). Stimulates Epac-mediated Ca2+-mediated Ca2+ release in pancreatic β-cells in vitro. Cell permeable analog (Cat. No. 4853) also available.
Licensing InformationSold with the permission of BioLog Life Science Institute
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Kawasaki et al (1998) A family of cAMP-binding proteins that directly activate Rap1. Science 282 2275. PMID: 9856955.
Enserink et al (2002) A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK. Nat.Cell.Biol. 4 901. PMID: 12402047.
Kang et al (2003) Epac-selective cAMP analog 8-pCPT-2'-O-Me-cAMP as a stimulus for Ca2+-induced Ca2+ release and exocytosis in pancreatic βcells. J.Biol.Chem. 278 8279. PMID: 12496249.
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Keywords: 8-CPT-2Me-cAMP, sodium salt, supplier, Selective, Epac, activators, G, Proteins, Small, Rap1, Rap2, GTPase
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