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Probucol

Cat No. 2775

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Chemical Name: 4,4'-[(1-Methylethylidene)bis(thio)]bis[2,6-bis(1,1-dim ethylethyl)phenol]

Biological Activity

Antioxidant, anti-inflammatory and hypocholesterolemic agent. Inhibits atherogenesis in genetically hypercholesterolemic rabbits (Watanabe) and attenuates ischemia/reperfusion-induced cardiomyocyte apoptosis.

Technical Data

M.Wt:

516.84

Formula:

C₃₁H₄₈O₂S₂

Solubility:

Soluble to 25 mM in DMSO and to 100 mM in ethanol

Purity:

>99 %

Storage:

Desiccate at +4°C

CAS No:

[23288-49-5]

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.

Resources

Certificate of Analysis / MSDS

Certificate of Analysis: View current batch

Material Safety Data Sheet: View current batch

References

Ku et al (1990) Ex vivo lipopolysaccharide-induced interleukin-1 secretion from murine peritoneal macrophages inhibited by probucol, a hypocholesterolemic agent with antioxidant properties. FASEB J. 4 1645. Ruixing et al (2006) Pretreatment with probucol attenuates cardiomyocyte apoptosis in a rabbit model of ischemia/reperfusion. Scand.J.Clin.Lab.Invest. 66 549. Wu et al (2007) Probucol [4,4'-[(1-methylethylidene)bis(thio)]bis-[2,6-bis(1,1-dimethylethyl)phenol]] inhibits compensatory remodeling and promotes lumen loss associated with atherosclerosis in apolipoprotein E-deficient mice. J.Pharmacol.Exp.Ther. 321 477.

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