AY 9944 dihydrochloride
Cat. No. 1639
Chemical Name: trans-N,N-bis[2-Chlorophenylmethyl]-1,4-cyclohexanedimethanamine dihydrochloride
Biological ActivityInhibitor of hedgehog (Hh) signaling, possibly via several mechanisms. Inhibits Δ7-dehydrocholesterol reductase (IC50 = 13 nM), thus reduces cholesterol biosynthesis, and also inhibits cholesterol esterification. May also directly block the cellular response to Hh proteins. Teratogenic in vivo.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Kraml et al (1964) Inhibition of the conversion of 7-dehydrocholesterol to cholesterol by AY-9944. Biochem.Biophys.Res.Commun. 15 455. PMID: 4283982.
Cooper et al (1998) Teratogen-mediated inhibition of target tissue response to Shh signaling. Science 280 1603. PMID: 9616123.
Moebius et al (1998) Molecular cloning and expression of the human Δ7-sterol reductase. Proc.Natl.Acad.Sci.U.S.A. 95 1899. PMID: 9465114.
Incardona and Eaton (2000) Cholesterol in signal transduction. Curr.Opin.Cell Biol. 12 193. PMID: 10712926.
If you know of a relevant citation for this product please let us know.
View Related Products by Target
Keywords: AY 9944 dihydrochloride, supplier, inhibitors, hedgehog, Hh, signaling, Δ7-dehydrocholesterol, Delta7-dehydrocholesterol, reductases, Signalling, DHCR, Reductase, Reductases, AY9944, dihydrochloride
Find multiple products by catalog number
New Products in this Area
Inhibits Hedgehog signalingJervine
Inhibitor of Hedgehog (Hh) signaling; binds directly to SmoGue 1654
Selective inhibitor of OXE-R Gβγ signaling
Win a Kindle
May 21 - 24, 2013
Booth Number: 32