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AY 9944 dihydrochloride

Cat. No. 1639

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Chemical Name: trans-N,N-bis[2-Chlorophenylmethyl]-1,4-cyclohexanedimethanamine dihydrochloride

Biological Activity

Inhibitor of hedgehog (Hh) signaling, possibly via several mechanisms. Inhibits Δ⁷-dehydrocholesterol reductase (IC₅₀ = 13 nM), thus reduces cholesterol biosynthesis, and also inhibits cholesterol esterification. May also directly block the cellular response to Hh proteins. Teratogenic in vivo.

Technical Data

M.Wt:

464.3

Formula:

C₂₂H₂₈Cl₂N₂.2HCl

Solubility:

Soluble to 50 mM in water

Purity:

>99 %

Storage:

Desiccate at RT

CAS No:

366-93-8

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Kraml et al (1964) Inhibition of the conversion of 7-dehydrocholesterol to cholesterol by AY-9944. Biochem.Biophys.Res.Commun. 15 455. PMID: 4283982.

Cooper et al (1998) Teratogen-mediated inhibition of target tissue response to Shh signaling. Science 280 1603. PMID: 9616123.

Moebius et al (1998) Molecular cloning and expression of the human Δ7-sterol reductase. Proc.Natl.Acad.Sci.U.S.A. 95 1899. PMID: 9465114.

Incardona and Eaton (2000) Cholesterol in signal transduction. Curr.Opin.Cell Biol. 12 193. PMID: 10712926.

If you know of a relevant citation for this product please let us know.

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