AY 9944 dihydrochloride

Cat. No. 1639

AY 9944 dihydrochloride C22H28Cl2N2.2HCl [366-93-8]

Price and Availability

For AY 9944 dihydrochloride pricing & availability please select your country from the drop down menu:
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: trans-N,N-bis[2-Chlorophenylmethyl]-1,4-cyclohexanedimethanamine dihydrochloride

Biological Activity

Inhibitor of hedgehog (Hh) signaling, possibly via several mechanisms. Inhibits Δ7-dehydrocholesterol reductase (IC50 = 13 nM), thus reduces cholesterol biosynthesis, and also inhibits cholesterol esterification. May also directly block the cellular response to Hh proteins. Teratogenic in vivo.

Technical Data

Soluble to 50 mM in water
>99 %
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet


Kraml et al (1964) Inhibition of the conversion of 7-dehydrocholesterol to cholesterol by AY-9944. Biochem.Biophys.Res.Commun. 15 455. PMID: 4283982.

Cooper et al (1998) Teratogen-mediated inhibition of target tissue response to Shh signaling. Science 280 1603. PMID: 9616123.

Moebius et al (1998) Molecular cloning and expression of the human Δ7-sterol reductase. Proc.Natl.Acad.Sci.U.S.A. 95 1899. PMID: 9465114.

Incardona and Eaton (2000) Cholesterol in signal transduction. Curr.Opin.Cell Biol. 12 193. PMID: 10712926.

If you know of a relevant citation for this product please let us know.

View Related Products by Product Action

Keywords: AY 9944 dihydrochloride, supplier, inhibitors, hedgehog, Hh, signaling, Δ7-dehydrocholesterol, Delta7-dehydrocholesterol, reductases, Signalling, DHCR, Reductase, Reductases, AY9944, dihydrochloride, Hedgehog Signaling Inhibitors

Quick Order

Find multiple products by catalog number

divider line

Cancer Research Product Guide


Highlights over 750 products for cancer research. Request copy or view PDF today.

divider line

Stem Cells Review

Stem Cells Scientific Review

Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski. Request copy or view PDF today.

divider line

New Products in this Area

W 54011

High affinity C5a receptor antagonist


PAD4 inhibitor


Ras signaling inhibitor; inhibits Ack1 and GCK

Sign-up for new product e-alerts
divider line

Bio-Techne Events

Pharmacology 2015

Pharmacology 2015

December 15 - 17, 2015

London UK