R&D Systems Inc. Tocris Bioscience Boston Biochem

Calphostin C

Cat. No. 1626

Calphostin C C44H38O14 [121263-19-2]

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Alternative Names: UCN 1028C, PKF 115584

Chemical Name: (1R)-2-[12-[(2R)-2-(Benzoyloxy)propyl]-3,10-dihydro-4,9-dihydroxy-2,6,7,11-tetramethoxy-3,10-dioxo-1-perylenyl]-1-methylethylcarbonic acid 4-hydroxyphenyl ester

Biological Activity

Potent, selective and photo-dependent inhibitor of protein kinase C that targets the regulatory domain (IC50 = 50 nM). Displays > 1000-fold selectivity over other protein kinases such as cAMP-dependent protein kinase and tyrosine-specific protein kinase. Inhibits cell proliferation of malignant glioma cells in light-treated conditions in vitro (IC50 ~ 40 - 60 nM). Also an antagonist of the Tcf/β-catenin complex.

Technical Data

M.Wt:
790.76
Formula:
C44H38O14
Solubility:
Soluble in DMSO and in ethanol
Purity:
>98 %
Storage:
Desiccate at +4°C
CAS No:
121263-19-2

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

References

Kobayashi et al (1989) Calphostin C (UCN-1028C), a novel microbial compound, is a highly potent and specific inhibitor of protein kinase C. Biochem.Biophys.Res.Comm. 159 548.

Pollack and Kawecki (1997) The effect of calphostin C, a potent photodependent protein kinase C inhibitor, on the proliferation of glioma cells in vitro. J.Neurooncol. 31 255. PMID: 9049854.

Au et al (2006) Differential effects of photofrin, 5-aminolevulinic acid and calphostin C on glioma cells. J.Photochem.Photobiol.B. 85 92. PMID: 16829117.

Matsuzaki and Darcha (2013) In vitro effects of a small-molecule antagonist of the Tcf/β-catenin complex on endometrial and endometriotic cells of patients with endometriosis. PLoS One 8 e61690. PMID: 23626717.

If you know of a relevant citation for this product please let us know.

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Keywords: Calphostin C, supplier, Potent, selective, photo-dependent, PKC, inhibitors, Protein, Kinases, C, CalphostinC, UCN1028C, PKF115-584, stem, cells

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