Calphostin C

Cat. No. 1626

Calphostin C C44H38O14 [121263-19-2]

Price and Availability

For Calphostin C pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Alternative Names: UCN 1028C, PKF 115584

Chemical Name: (1R)-2-[12-[(2R)-2-(Benzoyloxy)propyl]-3,10-dihydro-4,9-dihydroxy-2,6,7,11-tetramethoxy-3,10-dioxo-1-perylenyl]-1-methylethylcarbonic acid 4-hydroxyphenyl ester

Biological Activity

Potent, selective and photo-dependent inhibitor of protein kinase C that targets the regulatory domain (IC50 = 50 nM). Displays > 1000-fold selectivity over other protein kinases such as cAMP-dependent protein kinase and tyrosine-specific protein kinase. Inhibits cell proliferation of malignant glioma cells in light-treated conditions in vitro (IC50 ~ 40 - 60 nM). Also an antagonist of the Tcf/β-catenin complex.

Technical Data

M.Wt:
790.76
Formula:
C44H38O14
Solubility:
Soluble in DMSO and in ethanol
Purity:
>98 %
Storage:
Desiccate at +4°C
CAS No:
121263-19-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Select another batch:
Safety Data Sheet: View Safety Data Sheet

References

Kobayashi et al (1989) Calphostin C (UCN-1028C), a novel microbial compound, is a highly potent and specific inhibitor of protein kinase C. Biochem.Biophys.Res.Comm. 159 548.

Pollack and Kawecki (1997) The effect of calphostin C, a potent photodependent protein kinase C inhibitor, on the proliferation of glioma cells in vitro. J.Neurooncol. 31 255. PMID: 9049854.

Au et al (2006) Differential effects of photofrin, 5-aminolevulinic acid and calphostin C on glioma cells. J.Photochem.Photobiol.B. 85 92. PMID: 16829117.

Matsuzaki and Darcha (2013) In vitro effects of a small-molecule antagonist of the Tcf/β-catenin complex on endometrial and endometriotic cells of patients with endometriosis. PLoS One 8 e61690. PMID: 23626717.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: Calphostin C, supplier, Potent, selective, photo-dependent, PKC, inhibitors, Protein, Kinases, C, CalphostinC, UCN1028C, PKF115-584, stem, cells

Quick Order

Find multiple products by catalog number

divider line

Kinases Product Listing

Kinases Product Listing

Highlights over 400 products for kinase research. Request a copy or view PDF today.

divider line

Kinase Inhibitor Toolbox

80 Kinase inhibitors
pre-dissolved in DMSO

Kinase Inhibitor Toolbox

Includes many of the latest kinase inhibitors to become commercially available. Covers a wide range of kinase targets including EGFR, MAPK and CDK.

divider line

Pain Research Product Guide

Pain Research Guide

Highlights over 280 products for Pain research. Request copy or view PDF today.

divider line

New Product Guide

NPG

Highlights 130 new products added in the first half of 2015. View PDF today.

divider line

New Products in this Area

TC-S 7001

Potent and highly selective ROCK inhibitor; orally active

AS 2444697

Potent and selective IRAK4 inhibitor

BS 181 dihydrochloride

Selective cdk7 inhibitor

A66

Potent and selective PI 3-kinase p110α inhibitor

AZ 191

Potent DYRK1B inhibitor

ETP 45658

Potent PI 3-kinase inhibitor; also inhibits DNA-PK and mTOR

PFK 15

PFKFB3 inhibitor

PD 0332991 isethionate

Potent, selective Cdk4/6 inhibitor; brain penetrant

XL 413 hydrochloride

Potent and selective Cdc7 inhibitor

C16

PKR inhibitor

Rp-8-pCPT-cGMPS sodium

PKG inhibitor

TC-S 7004

Potent and selective DYRK1A/B inhibitor

TAK 960 hydrochloride

Potent and selective PLK1 inhibitor

A12B4C3

Potent and selective polynucleotide kinase/phosphatase (PKNP) inhibitor

BMS 345541

Selective allosteric inhibitor of IKK; anti-inflammatory

WH-4-023

Potent and selective Lck and Src inhibitor; also inhibits SIK

TC-S 7006

Potent and selective Tpl2 (Cot; MAP3K8) inhibitor

OXA 06 dihydrochloride

Potent ROCK inhibitor

PCI 29732

Potent BTK inhibitor

Mps1-IN-1 dihydrochloride

Selective monopolar spindle 1 (Mps1) kinase inhibitor

Sign-up for new product e-alerts
divider line

Bio-Techne Events

ESM 2015

5th European Synapse Meeting

September 7 - 9, 2015

Bristol, UK