DFB

Cat No. 1625

DFB C14H10F2N2 [15332-10-2]

Price and Availability

For DFB pricing & availability please select your country from the drop down menu:
Submit

Alternative Name: 3,3'-Difluorobenzaldazine

Chemical Name: [(3-Fluorophenyl)methylene]hydrazone-3-fluorobenzaldehy de

Biological Activity

Novel allosteric potentiator of the metabotropic glutamate receptor mGlu5. Devoid of agonist activity itself, but potentiates (3-6-fold) the action of agonists at mGlu5 without any effect at other mGlu subtypes (EC50 for potentiation = 2-5.3 μM).

Technical Data

M.Wt:
244.24
Formula:
C14H10F2N2
Solubility:
Soluble to 10 mM in ethanol and to 50 mM in DMSO
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
[15332-10-2]

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.

Certificate of Analysis / MSDS

Certificate of Analysis: View current batch
Material Safety Data Sheet: View current batch

References

Williams et al (2002) DFB, an allosteric potentiator of mGluR5. 4th International Meeting on Metabotropic Glutamate Receptors Abstr. (addendum). O'Brien et al (2003) A family of highly selective allosteric modulators of the metabotropic glutamate receptor subtype 5. Mol.Pharmacol. 64 731. Zhang et al (2005) Allosteric potentiators of metabotropic glutamate receptor subtype 5 have differential effects on different signaling pathways in cortical astrocytes. J.Pharmacol.Exp.Ther. 315 1212.

If you know of a useful citation for this product please let us know.

Keywords: DFB, Allosteric, potentiators, mGlu5, mGluR5, Group, I, Receptors, Glutamate, Metabotropic

Buy Now / Print Quote

Find multiple products by catalog number


divider line

Print Quote Facility

Order via your purchasing department

Print Quote Facility

It's now even easier to place orders via your purchasing department.

Simply add a product to your cart & click on the "Print Quote" button.

more
divider line

GPCRs and Signalling Networks

Written by M.J. Marinissen

GPCR Poster

'G-Protein-coupled Receptors and Signalling Networks' summarizes the intricate network of intracellular signalling pathways involved in GPCR function.

request
divider line

mGlu Receptors Review

mGlu Receptors

Written by Francine Archer, an expert in the field. Request a copy or view PDF today.

request
divider line

Modulators of Peripheral Sensitization

Written by M.R. Vasko and G.D. Nicol

Pain Poster

'Pharmacological Modulators of Peripheral Sensitization' summarizes the inhibitory and excitatory modulators of peripheral sensitization.

request
divider line

Neurobiology of Parkinson's Disease

Written by A. Schapira

Parkinson's Poster

'Neurobiology and Therapeutics of Parkinson's Disease' highlights the neurobiology of Parkinson's disease and highlights current and novel therapeutic interventions.

request
divider line

7-TM Receptor Signalling

Written by T. Kenakin et al

7-TM Poster

'Seven Transmembrane Receptor Signalling' highlights the multiple behaviors of 7-TMs including G-protein-dependent and -independent signaling as well as the concept of collateral efficacy

request
divider line

Antidepressants - Current and Future Targets

Written by P. Skolnich et al

Parkinson's Poster

'Antidepressants - Current and Future Targets' provides an overview of the current and future targets for the treatment of major depressive disorder.

request
divider line

New Products in this Area

CHPG Sodium salt

Sodium salt of CHPG (Cat.No. 1049). Selective mGlu5 agonist

Sign-up for new product e-alerts
divider line

2009-10 Catalog

2009-2010 Tocris Catalog

Our range of over 3,000 life science reagents represents a unique collection of novel and exclusive research tools. Request a copy or view PDF today.

request