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2-Methylthioadenosine diphosphate trisodium salt

Cat. No. 1624

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Alternative Names: 2-(Methylthio)adenosine 5'-diphosphate, 2-Methylthio-ADP

Chemical Name: 2-(Methylthio)adenosine-5'-(trihydrogen diphosphate) trisodium salt

Biological Activity

Potent purinergic agonist displaying selectivity for P2Y₁, P2Y₁₂ and P2Y₁₃ receptors (pEC₅₀ = 8.29 and 9.05 for P2Y₁ and P2Y₁₂, EC₅₀ = 19 nM for P2Y₁₃). Induces aggregation of, and inhibits cAMP accumulation in, platelets in vitro.

Technical Data

M.Wt:

539.24

Formula:

C₁₁H₁₄N₅Na₃O₁₀P₂S

Solubility:

Soluble in water (supplied pre-dissolved at a concentration of 10mM)

Purity:

>98 %

Storage:

Store at -20°C

CAS No:

34983-48-7

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

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Safety Data Sheet: View Safety Data Sheet

References

Macfarlane et al (1983) 2-Methylthioadenosine[β-³²P]diphosphate. An agonist and radioligand for the receptor that inhibits the accumulation of cyclic AMP in intact blood platelets. J.Clin.Invest. 71 420. PMID: 6298277.

Sak and Webb (2002) A retrospective of recombinant P2Y receptor subtypes and their pharmacology. Arch.Biochem.Biophys. 397 131. PMID: 11747319.

Zhang et al (2002) P2Y₁₃: identification and characterization of a novel Gαi-coupled ADP receptor from human and mouse. J.Pharmacol.Exp.Ther. 301 705. PMID: 11961076.

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Keywords: 2-Methylthioadenosine diphosphate trisodium salt, supplier, Potent, agonists, P2Y1, P2Y12, P2Y13, Receptors, Purinergic, purinoceptors, p2yt

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