2-Methylthioadenosine diphosphate trisodium salt
Cat. No. 1624
Alternative Names: 2-(Methylthio)adenosine 5'-diphosphate, 2-Methylthio-ADP
Chemical Name: 2-(Methylthio)adenosine-5'-(trihydrogen diphosphate) trisodium salt
Biological ActivityPotent purinergic agonist displaying selectivity for P2Y1, P2Y12 and P2Y13 receptors (pEC50 = 8.29 and 9.05 for P2Y1 and P2Y12, EC50 = 19 nM for P2Y13). Induces aggregation of, and inhibits cAMP accumulation in, platelets in vitro.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Macfarlane et al (1983) 2-Methylthioadenosine[β-32P]diphosphate. An agonist and radioligand for the receptor that inhibits the accumulation of cyclic AMP in intact blood platelets. J.Clin.Invest. 71 420. PMID: 6298277.
Sak and Webb (2002) A retrospective of recombinant P2Y receptor subtypes and their pharmacology. Arch.Biochem.Biophys. 397 131. PMID: 11747319.
Zhang et al (2002) P2Y13: identification and characterization of a novel Gαi-coupled ADP receptor from human and mouse. J.Pharmacol.Exp.Ther. 301 705. PMID: 11961076.
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Keywords: 2-Methylthioadenosine diphosphate trisodium salt, supplier, Potent, agonists, P2Y1, P2Y12, P2Y13, Receptors, Purinergic, purinoceptors, p2yt
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