Cat. No. 2460
Alternative Name: Ro 19-6327
Chemical Name: N-(2-Aminoethyl)-5-chloro-2-pyridinecarboxamide hydrochloride
Biological ActivitySelective, reversible monoamine oxidase B (MAO-B) inhibitor (IC50 values are 0.03 and > 100 μM for MAO-B and MAO-A respectively). Inhibits monoamine uptake at high concentrations (IC50 values are 86, 123 and > 500 μM for noradrenalin, serotonin and dopamine uptake respectively).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Saura et al (1992) Quantitative enzyme radioautography with 3H-Ro 41-1049 and 3H-Ro 19-6327 in vitro: localization and abundance of MAO-A and MAO-B in rat CNS, peripheral organs, and human brain. J.Neurosci. 12 1977. PMID: 1578281.
Bondiolotti et al (1995) In vitro effects on monoamine uptake and release by the reversible monoamine oxidase-B inhibitors lazabemide and N-(2-aminoethyl)-p-chlorobenzamide: a comparison with L-deprenyl. Biochem.Pharmacol. 50 97. PMID: 7605351.
Guimaraes and Soares-da-Silva (1998) The activity of MAO A and B in rat renal cells and tubules. Life Sci. 62 727. PMID: 9489509.
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Keywords: Lazabemide hydrochloride, supplier, Selective, MAO-B, inhibitors, Monoamine, Oxygenases, Oxidases, Ro196327
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