R&D Systems Inc. Tocris Bioscience Boston Biochem

Lazabemide hydrochloride

Cat. No. 2460

Lazabemide hydrochloride C8H10ClN3O.HCl [103878-83-7]

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Alternative Name: Ro 19-6327

Chemical Name: N-(2-Aminoethyl)-5-chloro-2-pyridinecarboxamide hydrochloride

Biological Activity

Selective, reversible monoamine oxidase B (MAO-B) inhibitor (IC50 values are 0.03 and > 100 μM for MAO-B and MAO-A respectively). Inhibits monoamine uptake at high concentrations (IC50 values are 86, 123 and > 500 μM for noradrenalin, serotonin and dopamine uptake respectively).

Technical Data

M.Wt:
236.1
Formula:
C8H10ClN3O.HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
>98 %
Storage:
Desiccate at RT
CAS No:
103878-83-7

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Saura et al (1992) Quantitative enzyme radioautography with 3H-Ro 41-1049 and 3H-Ro 19-6327 in vitro: localization and abundance of MAO-A and MAO-B in rat CNS, peripheral organs, and human brain. J.Neurosci. 12 1977. PMID: 1578281.

Bondiolotti et al (1995) In vitro effects on monoamine uptake and release by the reversible monoamine oxidase-B inhibitors lazabemide and N-(2-aminoethyl)-p-chlorobenzamide: a comparison with L-deprenyl. Biochem.Pharmacol. 50 97. PMID: 7605351.

Guimaraes and Soares-da-Silva (1998) The activity of MAO A and B in rat renal cells and tubules. Life Sci. 62 727. PMID: 9489509.

If you know of a relevant citation for this product please let us know.

Keywords: Lazabemide hydrochloride, supplier, Selective, MAO-B, inhibitors, Monoamine, Oxygenases, Oxidases, Ro196327

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