Cat. No. 2773
Chemical Name: (R)-5,6-Dihydro-5-(methylamino)-4H-
Biological ActivityHigh affinity D2 receptor agonist (EC50 values are between 17 and 75 nM in cell-based assays). Displays >200-fold selectivity for the D2 receptor against other dopamine receptor subtypes (Ki values are 9.0, 1940, >2190 and >7140 for D2, D3, D4 and D1 receptors respectively). Exhibits antiParkinsonian activity similar to ropinirole (Cat. No. 3680).
Licensing InformationSold for research purposes under agreement from Pfizer Inc.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
McCall et al (2005) Sumanirole, a highly dopamine D2-selective receptor agonist: in vitro and in vivo pharmacological characterization and efficacy in animal models of Parkinson's disease. J.Pharmacol.Exp.Ther. 314 1248. PMID: 15980060.
Stephenson et al (2005) The effects of a selective dopamine D2 receptor agonist on behavioral and pathological outcome in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated squirrel monkeys. J.Pharmacol.Exp.Ther. 314 1257. PMID: 15980058.
If you know of a relevant citation for this product please let us know.
Keywords: Sumanirole maleate, supplier, pfizer, dopamine, dopaminergic, receptors, d2, selective, antiparkinsonian, parkinsons, parkinson's
Find multiple products by catalog number
New Products in this Area
Dopamine D2 receptor allosteric modulatorClozapine N-oxide
Clozapine (Cat. No. 0444) metabolite
Win $1,000 Product Credit
April 26 - 30, 2014
San Diego CA, USA
Booth Number: 918