R&D Systems Inc. Tocris Bioscience Boston Biochem

PI 103 hydrochloride

Cat. No. 2930

PI 103 hydrochloride C19H16N4O3.HCl [371935-79-4]

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Chemical Name: 3-[4-(4-Morpholinylpyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenol hydrochloride

Biological Activity

Inhibitor of DNA-PK, PI 3-kinase (p110α) and mTOR (IC50 values are 2, 8, 20, 26, 48, 83, 88, 150, 850, 920, ~ 1000 and 2300 nM for DNA-PK, p110α, mTORC1, PI 3-KC2β, p110δ, mTORC2, p110β, p110γ, ATR, ATM, PI 3-KC2α and hsVPS34 respectively). Inhibits growth of human tumor xenografts in mice in vivo. Induces autophagosome formation in glioma cells.

Technical Data

M.Wt:
384.82
Formula:
C19H16N4O3.HCl
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Desiccate at +4°C
CAS No:
371935-79-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

References

Fan et al (2006) A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma. Cancer cell 9 341. PMID: 16697955.

Knight et al (2006) A pharmacological map of the PI3-K family defines a role for p110α in insulin signaling. Cell 125 733. PMID: 16647110.

Raynaud et al (2007) Pharmacologic characterization of a potent inhibitor of class I phosphatidylinositol 3-kinase. Cancer Res. 67 5840. PMID: 17575152.

Fan et al (2010) Akt and autophagy cooperate to promote survival of drug-resistant glioma. Sci.Signal. 3 ra81. PMID: 21062993.

If you know of a relevant citation for this product please let us know.

Keywords: PI 103 hydrochloride, supplier, inhibitors, DNA-PK, mTOR, PI, 3-kinase, DNA-Dependent, Protein, Kinases, Mammalian, Target, Rapamycin, PI103, hydrochloride

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