Cat. No. 2931
Biological ActivityEndogenous peptide that potently antagonizes P2X3 receptors (IC50 = 8.3 pM). Also inhibits enkephalin-degrading enzymes (aminopeptidase, dipeptidyl aminopeptidase III, neprilysin) and angiotensin-converting enzyme. Displays antinociceptive effects in mice.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Honda et al (2001) Spinorphin, an endogenous inhibitor of enkephalin-degrading enzymes, potentiates Leu-enkephalin-induced anti-allodynic and antinociceptive effects in mice. Jpn.J.Pharmacol. 87 261. PMID: 11829145.
Liang et al (2001) The endogenous opioid spinorphin blocks fMet-Leu-Phe-induced neutrophil chemotaxis by acting as a specific antagonist at the N-formylpeptide receptor subtype FPR. J.Immunol. 167 6609. PMID: 11714831.
Jung et al (2007) Structure-activity relationship studies of spinorphin as a potent and selective human P2X3 receptor antagonist. J.Med.Chem. 50 4543. PMID: 17676725.
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Keywords: Spinorphin, supplier, Potent, P2X3, antagonists, Enkephalin-degrading, ACE, inhibitors, Receptors, Purinergic, purinoceptors, Angiotensin-Converting, Enzyme, Proteinases, Proteases
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