Home » Research Area » » Ion Channels » Ligand-gated Ion Channels » Purinergic (P2X) Receptors » Spinorphin

Spinorphin

Cat. No. 2931

Price and Availability

For Spinorphin pricing & availability please select your country from the drop down menu:
Submit

By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Biological Activity

Endogenous peptide that potently antagonizes P2X₃ receptors (IC₅₀ = 8.3 pM). Also inhibits enkephalin-degrading enzymes (aminopeptidase, dipeptidyl aminopeptidase III, neprilysin) and angiotensin-converting enzyme. Displays antinociceptive effects in mice.

Technical Data

M.Wt:

877.05

Formula:

C₄₅H₆₄N₈O₁₀

Sequence:

LVVYPWT

Solubility:

Soluble to 1 mg/ml in water

Storage:

Desiccate at -20°C

CAS No:

137201-62-8

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Select another batch:

Safety Data Sheet: View Safety Data Sheet

References

Honda et al (2001) Spinorphin, an endogenous inhibitor of enkephalin-degrading enzymes, potentiates Leu-enkephalin-induced anti-allodynic and antinociceptive effects in mice. Jpn.J.Pharmacol. 87 261. PMID: 11829145.

Liang et al (2001) The endogenous opioid spinorphin blocks fMet-Leu-Phe-induced neutrophil chemotaxis by acting as a specific antagonist at the N-formylpeptide receptor subtype FPR. J.Immunol. 167 6609. PMID: 11714831.

Jung et al (2007) Structure-activity relationship studies of spinorphin as a potent and selective human P2X₃ receptor antagonist. J.Med.Chem. 50 4543. PMID: 17676725.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Angiotensin-Converting Enzyme Other Proteases

Purinergic (P2X) Receptors Proteases

Keywords: Spinorphin, supplier, Potent, P2X3, antagonists, Enkephalin-degrading, ACE, inhibitors, Receptors, Purinergic, purinoceptors, Angiotensin-Converting, Enzyme, Proteinases, Proteases