R&D Systems Inc. Tocris Bioscience Boston Biochem

Calcipotriol

Cat. No. 2700

Calcipotriol C27H40O3 [112965-21-6]

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Alternative Name: MC 903

Chemical Name: (1α,3β,5Z,7E,22E,24S)-24-Cyclopropyl-9,10-secochola-5,7,10(19),22-tetraene-1,3,24-triol

Biological Activity

Vitamin D3 analog that displays minimal effects on calcium homeostasis. Regulates cell differentiation and proliferation; exhibits antiproliferative activity against human HL-60, HL60/MX2, MCF-7, T47D, SCC-25 and mouse WEHI-3 cancer cell lines.

Technical Data

M.Wt:
412.6
Formula:
C27H40O3
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>98 %
Storage:
Desiccate at -20°C
CAS No:
112965-21-6

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Binderu (1993) Comparison of calcipotriol with selected metabolites and analogues of vitamin D3: effects on cell growth regulation in vitro and calcium metabolism in vivo. Pharmacol.Toxicol. 72 240. PMID: 8396769.

Knutson et al (1997) Pharmacokinetics and systemic effect on calcium homeostasis of 1α,24-dihydroxyvitamin D2 in rats. Biochem.Pharmacol. 53 829. PMID: 9113104.

Wietrzyk et al (2007) Antitumor properties of diastereomeric and geometric analogs of vitamin D3. Anticancer Drugs 18 447. PMID: 17351397.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: Calcipotriol, supplier, Vitamin, D3, D, Receptors, VDR-like, MC903

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