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TRAM 34

Cat. No. 2946

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Chemical Name: 1-[(2-Chlorophenyl)diphenylmethyl]-1H-pyrazole

Biological Activity

Highly selective blocker of intermediate conductance Ca²⁺-activated K⁺ channels (K_Ca3.1) (K_d = 20 nM). Exhibits 200-1500-fold selectivity over K_V, BK_Ca, K_Ca2, Na⁺, CRAC and Cl^- channels. Suppresses the reactivation of lymphocytes by mitogenic stimuli.

Technical Data

M.Wt:

344.84

Formula:

C₂₂H₁₇ClN₂

Solubility:

Soluble to 50 mM in DMSO and to 10 mM in ethanol

Purity:

>99 %

Storage:

Store at +4°C

CAS No:

289905-88-0

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Wulff et al (2000) Design of a potent and selective inhibitor of the intermediate-conductance Ca²⁺-activated K⁺ channel, IKCa1: a potential immunosuppressant. Proc.Natl.Acad.Sci. USA 97 8151.

Schilling and Eder (2007) TRAM-34 inhibits nonselective cation channels. Pflugers Arch. 454 559. PMID: 17318643.

Wang et al (2007) An intermediate-conductance Ca²⁺-activated K⁺ channel mediates B lymphoma cell cycle progression induced by serum. Pflugers Arch. 454 945. PMID: 17429684.

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