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RU 26752

Cat. No. 2970

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Chemical Name: (7α,17α)-17-Hydroxy-3-oxo-7-propylpregn-4-ene-21-carboxylic acid γ-lactone

Biological Activity

Mineralocorticoid receptor antagonist. Prevents aldosterone-induced hypertension in rats.

Technical Data

M.Wt:

384.55

Formula:

C₂₅H₃₆O₃

Solubility:

Soluble to 25 mM in DMSO

Purity:

>99 %

Storage:

Store at -20°C

CAS No:

76676-33-0

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Lazar and Agarwal (1986) Evidence for an antagonist specific receptor that does not bind mineralocorticoid agonists. Biochem.Biophy.Res.Comms. 134 261.

Kalimi et al (1990) Effects of antimineralocorticoid RU 26752 on steroid-induced hypertension in rats. Am.J.Physiol. 258 E737. PMID: 2333987.

Huyet et al (2007) Structural basis of spirolactone recognition by the mineralocorticoid receptor. Mol.Pharmacol. 72 563. PMID: 17569793.

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