R&D Systems Inc. Tocris Bioscience Boston Biochem

LEP (116-130) (mouse)

Cat. No. 2985

LEP (116-130) (mouse) Ser-Cys-Ser-Leu-Pro-Gln-Thr-Ser-Gly-Leu-Gln-Lys-Pro-Glu-Ser-NH2

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Biological Activity

Synthetic leptin peptide fragment. Restricts weight gain and reduces food intake in female mice lacking endogenously circulating active leptin.

Technical Data

M.Wt:
1560.73
Formula:
C64H109N19O24S
Sequence:
SCSLPQTSGLQKPES

(Modifications: Ser-15 = C-terminal amide)

Solubility:
Soluble to 1 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
258276-95-8

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Grasso et al (1997) In vivo effects of leptin-related synthetic peptides on body weight and food intake in female ob/ob mice: localization of leptin activity to domains between amino acid residues 106-140. Endocrinology 138 1413. PMID: 9075696.

Grasso et al (1999) Inhibitory effects of leptin-related synthetic peptide 116-130 on food intake and body weight gain in female C57BL/6J ob/ob mice may not be mediated by peptide activation of the long isoform of the leptin receptor. Diabetes 48 2204. PMID: 10535455.

Rozhavskaya et al (2000) Design of a synthetic leptin agonist: effects on energy balance, glucose homeostasis and thermoregulation. Endocrinology 141 2501. PMID: 10875251.

If you know of a relevant citation for this product please let us know.

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Keywords: LEP (116-130) (mouse), supplier, Synthetic, leptin, peptide, fragment, Receptors, adipokines

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