LEP (116-130) (mouse)
Cat. No. 2985
Biological ActivitySynthetic leptin peptide fragment. Restricts weight gain and reduces food intake in female mice lacking endogenously circulating active leptin.
(Modifications: Ser-15 = C-terminal amide)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Grasso et al (1997) In vivo effects of leptin-related synthetic peptides on body weight and food intake in female ob/ob mice: localization of leptin activity to domains between amino acid residues 106-140. Endocrinology 138 1413. PMID: 9075696.
Grasso et al (1999) Inhibitory effects of leptin-related synthetic peptide 116-130 on food intake and body weight gain in female C57BL/6J ob/ob mice may not be mediated by peptide activation of the long isoform of the leptin receptor. Diabetes 48 2204. PMID: 10535455.
Rozhavskaya et al (2000) Design of a synthetic leptin agonist: effects on energy balance, glucose homeostasis and thermoregulation. Endocrinology 141 2501. PMID: 10875251.
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Keywords: LEP (116-130) (mouse), supplier, Synthetic, leptin, peptide, fragment, Receptors, adipokines