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BIBR 1532

Cat. No. 2981

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Chemical Name: 2-[[(2E)-3-(2-Naphthalenyl)-1-oxo-2-butenyl1-yl]amino]benzoic acid

Biological Activity

Selective telomerase inhibitor (IC₅₀ values are 93, > 100000 and > 100000 nM for human telomerase, human RNA polymerase I and human RNA polymerase II + III respectively). Causes telomere shortening in exponentially growing NCI-H460 lung carcinoma cells and eventual growth arrest.

Technical Data

M.Wt:

331.36

Formula:

C₂₁H₁₇NO₃

Solubility:

Soluble to 100 mM in DMSO and to 25 mM in ethanol

Purity:

>98 %

Storage:

Store at RT

CAS No:

321674-73-1

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

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Safety Data Sheet: View Safety Data Sheet

References

Damm et al (2001) A highly selective telomerase inhibitor limiting human cell proliferation. EMBO J. 20 6958. PMID: 11742973.

Phatak and Burger (2007) Telomerase and its potential for therapeutic intervention. Br.J.Pharmacol. 152 1003. PMID: 17603541.

Rankin et al (2008) Telomerase inhibitors and 'T-oligo' as caner therapeutics: contrasting molecular mechanisms of cytotoxicity. Anticancer Drugs 19 329. PMID: 18454043.

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