Cat. No. 2981
Chemical Name: 2-[[(2E)-3-(2-Naphthalenyl)-1-oxo-2-butenyl1-yl]amino]benzoic acid
Biological ActivitySelective telomerase inhibitor (IC50 values are 93, > 100000 and > 100000 nM for human telomerase, human RNA polymerase I and human RNA polymerase II + III respectively). Causes telomere shortening in exponentially growing NCI-H460 lung carcinoma cells and eventual growth arrest.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Damm et al (2001) A highly selective telomerase inhibitor limiting human cell proliferation. EMBO J. 20 6958. PMID: 11742973.
Phatak and Burger (2007) Telomerase and its potential for therapeutic intervention. Br.J.Pharmacol. 152 1003. PMID: 17603541.
Rankin et al (2008) Telomerase inhibitors and 'T-oligo' as caner therapeutics: contrasting molecular mechanisms of cytotoxicity. Anticancer Drugs 19 329. PMID: 18454043.
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Keywords: BIBR 1532, supplier, Selective, telomerase, inhibitors, BIBR1532