BIBR 1532

Cat. No. 2981

BIBR 1532 C21H17NO3 [321674-73-1]

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Chemical Name: 2-[[(2E)-3-(2-Naphthalenyl)-1-oxo-2-butenyl1-yl]amino]benzoic acid

Biological Activity

Selective telomerase inhibitor (IC50 values are 93, > 100000 and > 100000 nM for human telomerase, human RNA polymerase I and human RNA polymerase II + III respectively). Causes telomere shortening in exponentially growing NCI-H460 lung carcinoma cells and eventual growth arrest.

Technical Data

Soluble to 100 mM in DMSO and to 25 mM in ethanol
>98 %
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Damm et al (2001) A highly selective telomerase inhibitor limiting human cell proliferation. EMBO J. 20 6958. PMID: 11742973.

Phatak and Burger (2007) Telomerase and its potential for therapeutic intervention. Br.J.Pharmacol. 152 1003. PMID: 17603541.

Rankin et al (2008) Telomerase inhibitors and 'T-oligo' as caner therapeutics: contrasting molecular mechanisms of cytotoxicity. Anticancer Drugs 19 329. PMID: 18454043.

If you know of a relevant citation for this product please let us know.

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Keywords: BIBR 1532, supplier, Selective, telomerase, inhibitors, BIBR1532, Tocris Bioscience, Telomerase Inhibitors

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