R&D Systems Inc. Tocris Bioscience Boston Biochem

SCH 39166 hydrobromide

Cat. No. 2299

SCH 39166 hydrobromide C19H20ClNO.HBr [1227675-51-5]

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Alternative Name: Ecopipam hydrobromide

Chemical Name: (6aS-trans)-11-Chloro-6,6a,7,8,9,13b-hexahydro-7-methyl-5H-benzo[d]naphth[2,1-b]azepin-12-ol hydrobromide

Biological Activity

High affinity dopamine D1/D5 receptor antagonist; displays Ki values of 1.2, 2, 980, 5520, 80 and 731 nM for binding to D1, D5, D2, D4, 5-HT and α2a receptors, respectively.

Technical Data

M.Wt:
394.73
Formula:
C19H20ClNO.HBr
Solubility:
Soluble to 100 mM in DMSO
Purity:
>99 %
Storage:
Desiccate at RT
CAS No:
1227675-51-5

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

McQuade et al (1991) In vivo binding of SCH 39166: a D-1 selective antagonist. J.Pharmacol.Exp.Ther. 257 42. PMID: 1826927.

Terry and Katz (1994) A comparison of the effects of the D1 receptor antagonists SCH 23390 and SCH 39166 on suppression of feeding behaviour by the D1 agonist SKF38393. Psychopharmacology 113 328. PMID: 7862841.

Wu et al (2005) Dopamine D1/D5 receptor antagonists with improved pharmacokinetics: design, synthesis, and biological evaluation of phenol bioisosteric analogues of benzazepine D1/D5 antagonists. J.Med.Chem. 48 680. PMID: 15689153.

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Keywords: SCH 39166 hydrobromide, supplier, High, affinity, D1/D5, receptor, antagonists, Dopamine, Receptors, dopaminergic, SCH39166, hydrobromide

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