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A 438079 hydrochloride

Cat No. 2972

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Chemical Name: 3-[[5-(2,3-Dichlorophenyl)-1H-tetrazol-1-yl]methyl]pyri dine hydrochloride

Biological Activity

Competitive P2X₇ receptor antagonist (pIC₅₀ = 6.9 for the inhibition of Ca²⁺ influx in the human recombinant P2X₇ cell line). Devoid of activity at other P2 receptors (IC₅₀ >> 10 μM). Possesses antinociceptive activity in models of neuropathic pain in vivo.

Technical Data

M.Wt:

342.61

Formula:

C₁₃H₉Cl₂N₅.HCl

Solubility:

Soluble to 100 mM in water and to 100 mM in DMSO

Purity:

>98 %

Storage:

Desiccate at RT

CAS No:

[899507-36-9]

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.

Resources

Certificate of Analysis / MSDS

Certificate of Analysis: View current batch

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Material Safety Data Sheet: View current batch

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References

Nelson et al (2006) Structure-activity relationship studies on a series of novel, substituted 1-benzyl-5-phenyltetrazole P2X₇ antagonists. J.Med.Chem. 49 3659. Donnelly-Roberts and Jarvis (2007) Discovery of P2X₇ receptor-selective antagonists offers new insights into P2X₇ receptor function and indicates a role in chronic pain states. Br.J.Pharmacol. 151 571. McGaraughty et al (2007) P2X₇-related modulation of pathological nociception in rats. Neuroscience 146 1817.

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