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FPA 124

Cat. No. 2926

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Chemical Name: Dichloro[(2Z)-2-[(4-oxo-4H-1-benzopyran-3-yl)methylene]hydrazinecarbothioamide copper complex

Biological Activity

Akt/PKB inhibitor (IC₅₀ = 100 nM) that interacts with the PH and kinase domains. Inhibits cell proliferation in various cancer cell lines in vitro and decreases NF-κB activity and tumor load in vivo.

Licensing Information

Sold under license from Wayne State University

Technical Data

M.Wt:

381.73

Formula:

C₁₁H₉Cl₂CuN₃O₂S

Solubility:

Soluble to 10 mM in DMSO and to 10 mM in ethanol

Storage:

Store at +4°C

CAS No:

902779-59-3

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis is currently unavailable on-line. Please contact Customer Service

Safety Data Sheet: View Safety Data Sheet

References

Barve et al (2006) Synthesis, molecular characterization, and biological activity of novel synthetic derivatives of chromen-4-one in human cancer cells. J.Med.Chem. 49 3800. PMID: 16789737.

If you know of a relevant citation for this product please let us know.

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