R&D Systems Inc. Tocris Bioscience Boston Biochem

FPA 124

Cat. No. 2926

FPA 124 C11H9Cl2CuN3O2S [902779-59-3]

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Chemical Name: Dichloro[(2Z)-2-[(4-oxo-4H-1-benzopyran-3-yl)methylene]hydrazinecarbothioamide copper complex

Biological Activity

Akt/PKB inhibitor (IC50 = 100 nM) that interacts with the PH and kinase domains. Inhibits cell proliferation in various cancer cell lines in vitro and decreases NF-κB activity and tumor load in vivo.

Licensing Information

Sold under license from Wayne State University

Technical Data

M.Wt:
381.73
Formula:
C11H9Cl2CuN3O2S
Solubility:
Soluble to 10 mM in DMSO and to 10 mM in ethanol
Storage:
Store at +4°C
CAS No:
902779-59-3

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis is currently unavailable on-line. Please contact Customer Service
Safety Data Sheet: View Safety Data Sheet

References

Barve et al (2006) Synthesis, molecular characterization, and biological activity of novel synthetic derivatives of chromen-4-one in human cancer cells. J.Med.Chem. 49 3800. PMID: 16789737.

If you know of a relevant citation for this product please let us know.

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Keywords: FPA 124, supplier, Akt, PKB, inhibitors, Protein, Kinases, B, FPA124

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