R&D Systems Inc. Tocris Bioscience Boston Biochem

Atipamezole hydrochloride

Cat. No. 2937

Atipamezole hydrochloride C14H16N2.HCl [104075-48-1]

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Chemical Name: 5-(2-Ethyl-2,3-dihydro-1H-indene-2-yl)-1H-imidazole hydrochloride

Biological Activity

Selective α2-adrenergic receptor antagonist (Ki values are 1.1, 1.0, 0.89, 1300 and 6500 nM for α2A, α2B, α2C, α1A and α1B receptors respectively). Brain penetrant.

Technical Data

M.Wt:
248.75
Formula:
C14H16N2.HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
>99 %
Storage:
Desiccate at RT
CAS No:
104075-48-1

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Virtanen et al (1989) Highly selective and specific antagonism of central and peripheral alpha 2-adrenoceptors by atipamezole. Arch.Int.Pharmacodyn.Ther. 297 190. PMID: 2567152.

Puurunen et al (2001) An α2-adrenergic antagonist, atipamezole, facilitates behavioral recovery after focal cerebral ischemia in rats. Neuropharmacology 40 597. PMID: 11249969.

Jurgens et al (2007) α2A adrenergic receptor activation inhibits epileptiform activity in the rat hippocampal CA3 region. Mol.Pharmacol. 71 1572. PMID: 17341653.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: Atipamezole hydrochloride, supplier, selective, a-adrenergic, alpha-adrenergic, α-adrenergic, antagonists, receptors, alpha-adrenoceptors, a-adrenoceptors, αadrenoceptors

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