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Batimastat

Cat. No. 2961

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Alternative Name: BB-94

Chemical Name: (2R,3S)-N⁴-Hydroxy-N1-[(1S)-2-(methylamino)-2-oxo-1-(phenylmethyl)ethyl]-2-(2-methylpropyl)-3-[(2-thienylthio)methyl]butanediamide

Biological Activity

Potent, broad spectrum MMP inhibitor (IC₅₀ values are 3, 4, 4, 6 and 20 nM for MMP -1, -2, -9, -7 and -3 respectively). Exhibits antiproliferative, anti-invasive and antimetastatic activity in human ovarian carcinoma xenografts in vivo.

Technical Data

M.Wt:

477.64

Formula:

C₂₃H₃₁N₃O₄S₂

Solubility:

Soluble to 100 mM in DMSO

Purity:

>99 %

Storage:

Store at -20°C

CAS No:

130370-60-4

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Davies et al (1993) A synthetic matrix metalloproteinase inhibitor decreases tumor burden and prolongs survival of mice bearing human ovarian carcinoma xenografts. Cancer Res. 53 2087. PMID: 8347186.

Wang et al (1994) Matrix metalloproteinase inhibitor BB-94 (Batimastat) inhibits human colon tumor growth and spread in a patient-like orthotopic model in nude mice. Cancer Res. 54 4726. PMID: 8062271.

Kohn and Liotta (1995) Molecular insights into cancer invasion: strategies for prevention and intervention. Cancer Res. 55 1856. PMID: 7728753.

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Keywords: Batimastat, supplier, Potent, broad, spectrum, MMP, inhibitors, Matrixins, Matrix, Metalloproteinase, Metalloprotease, Proteinases, Proteases