Cat. No. 2961
Alternative Name: BB-94
Chemical Name: (2R,3S)-N4-Hydroxy-N1-[(1S)-2-(meth
Biological ActivityPotent, broad spectrum MMP inhibitor (IC50 values are 3, 4, 4, 6 and 20 nM for MMP -1, -2, -9, -7 and -3 respectively). Exhibits antiproliferative, anti-invasive and antimetastatic activity in human ovarian carcinoma xenografts in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Davies et al (1993) A synthetic matrix metalloproteinase inhibitor decreases tumor burden and prolongs survival of mice bearing human ovarian carcinoma xenografts. Cancer Res. 53 2087. PMID: 8347186.
Wang et al (1994) Matrix metalloproteinase inhibitor BB-94 (Batimastat) inhibits human colon tumor growth and spread in a patient-like orthotopic model in nude mice. Cancer Res. 54 4726. PMID: 8062271.
Kohn and Liotta (1995) Molecular insights into cancer invasion: strategies for prevention and intervention. Cancer Res. 55 1856. PMID: 7728753.
If you know of a relevant citation for this product please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Batimastat, supplier, Potent, broad, spectrum, MMP, inhibitors, Matrixins, Matrix, Metalloproteinase, Metalloprotease, Proteinases, Proteases, Matrix Metalloprotease Inhibitors
Find multiple products by catalog number
New Products in this Area
Highly potent and selective renin inhibitorTiplaxtinin
Plasminogen activator inhibitor-1 (PAI-1) inhibitorBalicatib
Potent and selective cathepsin K inhibitorHFI 142
Insulin-regulated aminopeptidase (IRAP) inhibitorSSM 3 trifluoroacetate
Potent furin inhibitor(Z-LL)2 ketone
Putative inhibitor of signal peptide peptidasePR 619
Broad spectrum DUB inhibitor
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.