Cat. No. 1608
Alternative Name: cyclo(31-34)[D-Phe12,Nle21,38,Glu31, Lys34]Ac-hCRF (4-41)
Biological ActivityPotent and selective corticotropin releasing factor receptor-1 (CRF1) agonist (Ki values are 1.5 and 224 nM for CRF1 and CRF2 receptors respectively). Increases ACTH levels and increases faecal pellet output in vivo following i.p. administration.
Licensing InformationSold with the permission of the SALK Institute
(Modifications: Pro-1 = N-terminal Ac, X = Nle, Glu-28 = γ-Glu, Lys-31 = ε-Lys, Cyclized = Glu-28 - Lys-31, Ile-38 = C-terminal amide)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Rivier et al (2002) Receptor-selective corticotropin releasing factor analogs. Endocrin.Soc.Abstr. P2-50.
Rivier et al (2007) Stressin1-A, a potent corticotropin releasing factor receptor 1 (CRF1)-selective peptide agonist. J.Med.Chem. 50 1668. PMID: 17335188.
Bruchas et al (2009) CRF1-R activation of the dynorphin/kappa opioid system in the mouse basolateral amygdala mediates anxiety-like behavior. PLoS One. 4 e8528. PMID: 20052275.
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Keywords: Stressin I, supplier, CRF1, agonists, Corticotropin-Releasing, Factor1, Receptors, Factor, StressinI
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