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Ro 04-6790

Cat No. 2911

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Chemical Name: 4-Amino-N-[2,6-bis(methylamino)-4-pyrimidinyl]-benzenes ulfonamide

Biological Activity

Potent and selective 5-HT₆ receptor antagonist (pK_i values are 7.26 and 7.35 at rat and human 5-HT₆ receptors respectively). Displays no affinity at a range of other receptors (IC₅₀ > 10 μM). Induces stretching behavior in rats in vivo.

Technical Data

M.Wt:

308.36

Formula:

C₁₂H₁₆N₆O₂S

Solubility:

Soluble to 100 mM in DMSO

Purity:

>99 %

Storage:

Store at -20°C

CAS No:

[202466-68-0]

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.

Resources

Certificate of Analysis / MSDS

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Material Safety Data Sheet: View current batch

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References

Sleight et al (1998) Characterization of Ro 04-6790 and Ro 63-2563: potent and selective antagonists at human and rat 5-HT₆ receptors. Br.J.Pharmacol. 124 556. Bentley et al (1999) Investigation of stretching behaviour induced by the selective 5-HT₆ receptor antagonist, Ro 04-6790, in rats. Br.J.Pharmacol. 126 1537. Fone (2008) An update on the role of the 5-hydroxytryptamine₆ receptor in cognitive function. Neuropharmacology 55 1015.

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Keywords: Ro 04-6790, Potent, selective, 5-HT6, antagonists, Serotonin, Receptors, 5-Hydroxytryptamine, Ro04-6790

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GPCRs and Signalling Networks

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'G-Protein-coupled Receptors and Signalling Networks' summarizes the intricate network of intracellular signalling pathways involved in GPCR function.

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'Seven Transmembrane Receptor Signalling' highlights the multiple behaviors of 7-TMs including G-protein-dependent and -independent signaling as well as the concept of collateral efficacy

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