H 89 dihydrochloride
Cat. No. 2910
Chemical Name: N-[2-[[3-(4-Bromophenyl)-2-propenyl
Biological ActivityProtein kinase A inhibitor that also inhibits several other kinases (IC50 values are 80, 120, 135, 270, 2600 and 2800 nM for S6K1, MSK1, PKA, ROCKII, PKBα and MAPKAP-K1b).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Vitolo et al (2002) Amyloid β-peptide inhibition of the PKA/CREB pathway and long-term potentiation: reversibility by drugs that enhance cAMP signaling. Proct.Natl.Acad.Sci.USA 99 13217.
Lochner and Moolman (2006) The many faces of H89: a review. Cardiovasc.Drug Rev. 24 261. PMID: 17214602.
Yamada et al (2006) Involvement of cAMP response element-binding protein activation in salivary secretion. Pathobiology 73 1. PMID: 16785762.
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Keywords: H 89 dihydrochloride, supplier, Protein, kinases, A, inhibitors, PKA, H89, dihydrochloride
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July 15, 2014