R&D Systems Inc. Tocris Bioscience Boston Biochem

H 89 dihydrochloride

Cat. No. 2910

H 89 dihydrochloride C20H20BrN3O2S.2HCl [130964-39-5]

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Chemical Name: N-[2-[[3-(4-Bromophenyl)-2-propenyl]amino]ethyl]-5-isoquinolinesulfonamide dihydrochloride

Biological Activity

Protein kinase A inhibitor that also inhibits several other kinases (IC50 values are 80, 120, 135, 270, 2600 and 2800 nM for S6K1, MSK1, PKA, ROCKII, PKBα and MAPKAP-K1b).

Technical Data

M.Wt:
519.28
Formula:
C20H20BrN3O2S.2HCl
Solubility:
Soluble to 25 mM in water and to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at -20°C
CAS No:
130964-39-5

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

References

Vitolo et al (2002) Amyloid β-peptide inhibition of the PKA/CREB pathway and long-term potentiation: reversibility by drugs that enhance cAMP signaling. Proct.Natl.Acad.Sci.USA 99 13217.

Lochner and Moolman (2006) The many faces of H89: a review. Cardiovasc.Drug Rev. 24 261. PMID: 17214602.

Yamada et al (2006) Involvement of cAMP response element-binding protein activation in salivary secretion. Pathobiology 73 1. PMID: 16785762.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: H 89 dihydrochloride, supplier, Protein, kinases, A, inhibitors, PKA, H89, dihydrochloride

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