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PIT

Cat. No. 1682

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Alternative Name: 2,2'-Pyridylisatogen tosylate

Chemical Name: 2-(2-Pyridinyl)-(3H)-indol-3-one-1-oxide 4-methylbenzenesulfonate

Biological Activity

Purinergic P2Y receptor ligand. Displays irreversible antagonism at P2Y receptors in some smooth muscles but potentiates responses to ATP in other systems (chick brain recombinant P2Y₁ receptor and sympathetic/purinergic nerve stimulation).

Technical Data

M.Wt:

396.42

Formula:

C₁₃H₈N₂O₂.C₇H₈O₃S

Solubility:

Soluble to 15 mM in ethanol with gentle warming and to 80 mM in DMSO

Purity:

>99 %

Storage:

Desiccate at +4°C

CAS No:

56583-49-4

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Spedding et al (1975) Antagonism of adenosine 5'-triphosphate-induced relaxation by 2-2'-pyridylisatogen in the taenia of guinea-pig caecum. Br.J.Pharmacol. 53 575. PMID: 1148500.

King et al (1996) Potentiation by 2,2'-pyridylisatogen tosylate of ATP-responses at a recombinant P_2Y1 purinoceptor. Br.J.Pharmacol. 117 1111. PMID: 8882604.

Ren and Burnstock (1997) Prominent sympathetic purinergic vasoconstriction in the rabbit splenic artery: potentiation by 2.2'-pyridylisatogen tosylate. Br.J.Pharmacol. 120 530. PMID: 9031760.

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