Cat. No. 1603
Alternative Names: Colforsin dapropate hydrochloride, 6-(3-dimethylaminopropionyl)forskolin hydrochloride
Chemical Name: N,N-Dimethyl-(3R,4aR,5S,6aS,10S,10a
Biological ActivityWater-soluble analog of forskolin (Cat. No. 1099) that is a potent activator of adenylyl cyclase; shows some selectivity for cardiac (type V) adenylyl cyclase. Stimulates bronchodilation (EC50 = 32.6 nM) and is an orally active potent positive chronotrope and hypotensive agent in vivo. Also available as part of the PKA Tocriset™.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Hosono et al (1992) Cardiovascular and adenylate cyclase stimulant properties of NKH477, a novel water-soluble forskolin derivative. J.Cardiovasc.Pharmacol. 19 625. PMID: 1380607.
Satake et al (1998) Relaxant effects of NKH477, a new water-soluble forskolin derivative, on guinea-pig tracheal smooth muscle: the role of Ca2+-activated K+ channels. Br.J.Pharmacol. 123 753. PMID: 9517396.
Toya et al (1998) Forskolin derivatives with increased selectivity for cardiac adenylyl cyclase. J.Mol.Cell.Cardiol. 30 97. PMID: 9500868.
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Keywords: NKH 477, supplier, Water-soluble, adenylyl, adenylate, cyclases, activators, cAMP, NKH477
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