Cat. No. 2851
Alternative Name: DM 9384
Chemical Name: N-(2,6-Dimethylphenyl)-2-oxo-1-pyrr
Biological ActivityCognitive enhancer that displays various pharmacological effects. Activates L/N-type calcium channels, cholinergic, monoaminergic and GABAergic systems. Displays potent neuroprotective action in the retinal ischemia-reperfusion model in vivo.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Certificate of Analysis / Safety Data Sheet
Narahashi et al (2004) Mechanisms of action of cognitive enhancers on neuroreceptors. Biol.Pharm.Bull. 27 1701. PMID: 15516710.
Ueda et al (2004) The cognitive-enhancer nefiracetam inhibits both necrosis and apoptosis in retinal ischemic models in vitro and in vivo. J.Pharmacol.Exp.Ther. 309 200. PMID: 14718588.
Kitano et al (2005) Effects of nefiracetam, a novel pyrrolidone-type nootropic agent, on the amygdala-kindled seizures in rats. Epilepsia 46 1561. PMID: 16190926.
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Keywords: Nefiracetam, supplier, Cognitive, enhancer, activates, L/N-type, Ca2+, channels, potentiates, NMDA, currents, Muscarinic, Receptors, Acetylcholine, Nicotinic, nAChR, Calcium, CaV, Channels, L-Type, N-Type, voltage-gated, voltage-dependent, Glutamate, N-Methyl-D-Aspartate, iGluR, Ionotropic, DM9384