R&D Systems Inc. Tocris Bioscience Boston Biochem

B-HT 920

Cat. No. 2759

B-HT 920 C10H15N3S.2HCl [36085-73-1]

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Alternative Name: Talipexole

Chemical Name: 5,6,7,8-Tetrahydro-6-(2-propen-1-yl)-4H-thiazolo[4,5-d]azepin-2-amine dihydrochloride

Biological Activity

Dopamine D2 receptor agonist, α2-adrenoceptor agonist and 5-HT3 receptor antagonist. Displays antiParkinsonian activity.

Technical Data

M.Wt:
282.23
Formula:
C10H15N3S.2HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
>98 %
Storage:
Desiccate at RT
CAS No:
36085-73-1

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Robertson et al (1993) In vivo comparisons of the effects of quinpirole and the putative presynaptic dopaminergic agonists B-HT 920 and SND 919 on striatal dopamine and acetylcholine release. J.Pharmacol.Exp.Ther. 264 1344. PMID: 8095550.

Nishio et al (1996) 5-HT3 receptor blocking properties of the antiParkinsonian agent, talipexole. Gen.Pharmacol. 27 779. PMID: 8842679.

Ricci and Taira (1999) Adrenoceptor involvement in the cardiovascular responses to B-HT 920 in sinoaortic denervated rats. Gen.Pharmacol. 32 29. PMID: 9888250.

Maina and Mathews (2010) A functional fast scan cyclic voltammetry assay to characterize dopamine D2 and D3 autoreceptors in the mouse striatum. ACS Chem.Neurosci. 1 450. PMID: 20567609.

If you know of a relevant citation for this product please let us know.

Keywords: B-HT 920, supplier, 5-HT3, antagonists, D2, α2-adrenoceptor, alpha2-adrenoceptor, a2-adrenoceptor, a2-adrenergic, agonists, receptor, Serotonin, Receptors, Dopamine, dopaminergic, B-HT920

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