Cat. No. 2759
Alternative Name: Talipexole
Chemical Name: 5,6,7,8-Tetrahydro-6-(2-propen-1-yl
Biological ActivityDopamine D2 receptor agonist, α2-adrenoceptor agonist and 5-HT3 receptor antagonist. Displays antiParkinsonian activity.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Robertson et al (1993) In vivo comparisons of the effects of quinpirole and the putative presynaptic dopaminergic agonists B-HT 920 and SND 919 on striatal dopamine and acetylcholine release. J.Pharmacol.Exp.Ther. 264 1344. PMID: 8095550.
Nishio et al (1996) 5-HT3 receptor blocking properties of the antiParkinsonian agent, talipexole. Gen.Pharmacol. 27 779. PMID: 8842679.
Ricci and Taira (1999) Adrenoceptor involvement in the cardiovascular responses to B-HT 920 in sinoaortic denervated rats. Gen.Pharmacol. 32 29. PMID: 9888250.
Maina and Mathews (2010) A functional fast scan cyclic voltammetry assay to characterize dopamine D2 and D3 autoreceptors in the mouse striatum. ACS Chem.Neurosci. 1 450. PMID: 20567609.
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Keywords: B-HT 920, supplier, 5-HT3, antagonists, D2, α2-adrenoceptor, alpha2-adrenoceptor, a2-adrenoceptor, a2-adrenergic, agonists, receptor, Serotonin, Receptors, Dopamine, dopaminergic, B-HT920
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High affinity D2 and 5-HT1A receptor partial agonist; also 5-HT2A antagonist
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