R&D Systems Inc. Tocris Bioscience Boston Biochem

PNU 96415E

Cat. No. 2735

PNU 96415E C21H25FN2O.2HCl [170856-41-4]

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Chemical Name: 1-[2-(3,4-Dihydro-1H-2-benzopyran-1-yl)ethyl]-4-(4-fluorophenyl)piperazine dihydrochloride

Biological Activity

Antipsychotic agent. Displays high affinity for dopamine D4 and serotonergic 5-HT2A receptors and relatively weak affinity at D2 receptors (Ki values are 3.0, 5.8, 134, 181, 199, 240, 411 and > 678 nM for D4, 5-HT2A, 5-HT1A, α1, D2, D3, D1, α2 and muscarinic receptors respectively). Inhibits exploratory locomotor activity and antagonizes d-amphetamine-induced locomotor stimulation in rats.

Technical Data

M.Wt:
413.36
Formula:
C21H25FN2O.2HCl
Solubility:
Soluble to 10 mM in water
Purity:
>98 %
Storage:
Desiccate at RT
CAS No:
170856-41-4

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Tang et al (1997) PNU-96415E, a potential antipsychotic agent with clozapine-like pharmacological properties. J.Pharmacol.Exp.Ther. 281 440. PMID: 9103528.

Goudie et al (1998) Discriminative stimulus properties of the atypical neuroleptic clozapine in rats: tests with subtype selective receptor ligands. Behav.Pharmacol. 9 699. PMID: 9890260.

If you know of a relevant citation for this product please let us know.

Keywords: PNU 96415E, supplier, 5-HT2A, D4, antagonists, antipsychotic, Serotonin, Receptors, Dopamine, dopaminergic, PNU96415E

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