R&D Systems Inc. Tocris Bioscience Boston Biochem

PNU 96415E

Cat. No. 2735

PNU 96415E C21H25FN2O.2HCl [170856-41-4]

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Chemical Name: 1-[2-(3,4-Dihydro-1H-2-benzopyran-1-yl)ethyl]-4-(4-fluorophenyl)piperazine dihydrochloride

Biological Activity

Antipsychotic agent. Displays high affinity for dopamine D4 and serotonergic 5-HT2A receptors and relatively weak affinity at D2 receptors (Ki values are 3.0, 5.8, 134, 181, 199, 240, 411 and > 678 nM for D4, 5-HT2A, 5-HT1A, α1, D2, D3, D1, α2 and muscarinic receptors respectively). Inhibits exploratory locomotor activity and antagonizes d-amphetamine-induced locomotor stimulation in rats.

Technical Data

M.Wt:
413.36
Formula:
C21H25FN2O.2HCl
Solubility:
Soluble to 10 mM in water
Purity:
>98 %
Storage:
Desiccate at RT
CAS No:
170856-41-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Tang et al (1997) PNU-96415E, a potential antipsychotic agent with clozapine-like pharmacological properties. J.Pharmacol.Exp.Ther. 281 440. PMID: 9103528.

Goudie et al (1998) Discriminative stimulus properties of the atypical neuroleptic clozapine in rats: tests with subtype selective receptor ligands. Behav.Pharmacol. 9 699. PMID: 9890260.

If you know of a relevant citation for this product please let us know.

Keywords: PNU 96415E, supplier, 5-HT2A, D4, antagonists, antipsychotic, Serotonin, Receptors, Dopamine, dopaminergic, PNU96415E

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