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Mosapride citrateCat. No. 2844 |
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Chemical Name: 4-Amino-5-chloro-2-ethoxy-N-[[4-[(4-fluorophenyl)methyl]-2-morpholinyl]methyl]benzamide citrate |
Biological Activity
5-HT4 receptor agonist and 5-HT3 receptor antagonist. Displays no activity at D2, α1, α2, 5-HT1 and 5-HT2 receptors. Gastroprokinetic agent; increases gastric emptying in rats and stimulates gastric motor actvity in conscious dogs.Certificate of Analysis / Safety Data Sheet
References
Yoshida et al (1989) AS-4370, a novel gastrokinetic agent free of dopamine D2 receptor antagonist properties. Arch.Int.Pharmacodyn.Ther. 300 51. PMID: 2533479.
Yoshida et al (1993) Pharmacological effects of the new gastroprokinetic agent mosapride citrate and its metabolites in experimental animals. Arzneim.-Forsch. 43 1078.
Mine et al (1997) Comparison of effect of mosapride citrate and existing 5-HT4 receptor agonists on gastrointestinal motility in vivo and in vitro. J.Pharmacol.Exp.Ther. 283 1000. PMID: 9399969.
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Keywords: Mosapride citrate, supplier, 5-HT3, antagonists, 5-HT4, agonists, Serotonin, Receptors, 5-Hydroxytryptamine
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