R&D Systems Inc. Tocris Bioscience Boston Biochem

Mecamylamine hydrochloride

Cat. No. 2843

Mecamylamine hydrochloride C11H21N.HCl [826-39-1]

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Chemical Name: N,2,3,3-Tetramethylbicyclo[2.2.1]heptan-2-amine hydrochloride

Biological Activity

Non-competitive nicotinic acetylcholine receptor antagonist. Displays antidepressant-like effects in mice.

Technical Data

M.Wt:
203.75
Formula:
C11H21N.HCl
Solubility:
Soluble to 100 mM in water and to 75 mM in DMSO
Storage:
Desiccate at RT
CAS No:
826-39-1

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

References

Rabenstein et al (2006) The nicotinic antagonist mecamylamine has antidepressant-like effects in wild-type but not β2- or α7-nicotinic acetylcholine receptor subunit knockout mice. Psychopharmacol. 189 395.

Ostroumov et al (2007) Modeling study of mecamylamine block of muscle type acetylcholine receptors. Eur.Biophys.J. 37 393. PMID: 17938901.

If you know of a relevant citation for this product please let us know.

Keywords: Mecamylamine hydrochloride, supplier, Non-competitive, nicotinic, receptors, antagonists, Acetylcholine, Non-Selective, Subtypes, nAChR

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