R&D Systems Inc. Tocris Bioscience Boston Biochem

AICAR

Cat. No. 2840

AICAR C9H14N4O5 [2627-69-2]

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Chemical Name: N1-(β-D-Ribofuranosyl)-5-aminoimidazole-4-carboxamide

Biological Activity

Cell-permeable, allosteric activator of AMP-activated protein kinase (AMPK). Augments proliferation, differentiation and mineralization of osteoblastic MC3T3-EI cells and attenuates psychosine-induced expression of proinflammatory cytokines and iNOS in astrocytes. Promotes osteogenic differentiation of hAMSCs and BM-MSCs in vitro.

Technical Data

M.Wt:
258.23
Formula:
C9H14N4O5
Solubility:
Soluble to 75 mM in water and to 75 mM in DMSO
Purity:
>99 %
Storage:
Store at -20°C
CAS No:
2627-69-2

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

References

Giri et al (2004) 5-Aminoimidazole-4-carboxamide-1-β-4-ribofuranoside inhibits proinflammatory response in glial cells: a possible role of AMP-activated protein kinase. J.Neurosci. 24 479. PMID: 14724246.

Kanazawa et al (2007) Adiponectin and AMP kinase activator stimulate proliferation, differentiation and mineralization of osteoblastic MC3T3-EI cells. BMC Cell Biol. 8 51. PMID: 18047638.

Giri et al (2008) The role of AMPK in psychosine mediated effects on oligodendrocytes and astrocytes: Implication for Krabbe disease. J.Neurochem. 105 1820. PMID: 18248608.

Wu et al (2011) AICAR, a small chemical molecule, primes osteogenic differentiation of adult mesenchymal stem cells. Int.J.Artif.Organs. 34 1128. PMID: 22198598.

If you know of a relevant citation for this product please let us know.

Keywords: AICAR, supplier, AMPK, activators, AMP-Activated, Protein, Kinases, Enzyme, Substrates

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