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Levetiracetam

Cat. No. 2839

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Alternative Names: Keppra, UCB L059

Chemical Name: (2S)-(2-Oxopyrrolidin-1-yl)butyramide

Biological Activity

Antiepileptic that displays distinctive properties from conventional antiepileptic drugs. Displays potent seizure protection in animal models of chronic epilepsy but lacks activity in acute seizure models. Binds synaptic vesicle protein 2A (SV2A) and inhibits Na⁺-dependent Cl^-/HCO₃^- exchange.

Technical Data

M.Wt:

170.21

Formula:

C₈H₁₄N₂O₂

Solubility:

Soluble to 100 mM in water and to 100 mM in DMSO

Purity:

>99 %

Storage:

Store at RT

CAS No:

102767-28-2

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Lynch et al (2004) The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam. Proct.Natl.Acad.Sci. USA 101 9861.

Smedt et al (2007) Levetiracetam: the profile of a novel anticonvulsant drug - part I: preclinical data. CNS Drug Rev. 13 43. PMID: 17461889.

Ueda et al (2007) Effect of levetiracetam on molecular regulation of hippocampal glutamate and GABA transporters in rats with chronic seizures induced by amygdalar FeCl₃ injection. Brain Res. 1151 55. PMID: 17408599.

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