R&D Systems Inc. Tocris Bioscience Boston Biochem

LY 379268

Cat. No. 2453

LY 379268 C7H9NO5 [191471-52-0]

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Chemical Name: (1R,4R,5S,6R)-4-Amino-2-oxabicyclo[­3.1.0]hexane-4,6-dicarboxylic acid

Biological Activity

Highly selective group II mGlu receptor agonist (EC50 values are 2.69 and 4.48 nM for hmGlu2 and hmGlu3 respectively) that displays > 80-fold selectivity over group I and group III receptors. Provides protection against NMDA-mediated cell death in vitro and offers almost complete protection against CA1 hippocampal damage following global ischemia in gerbils. Orally and systemically active. Caged LY 379268 is also available (Cat. No. 3332).

Licensing Information

Sold under license from Eli Lilly and Company

Technical Data

M.Wt:
187.15
Formula:
C7H9NO5
Solubility:
Soluble to 20 mM in water and to 100 mM in 1eq. NaOH
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
191471-52-0

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

References

Bond et al (1999) LY379268, a potent and selective group II metabotropic glutamate receptor agonist, is neuroprotective in gerbil global, but not focal cerebral ischaemia. Neurosci.Lett. 273 191. PMID: 10515191.

Bond et al (2000) Neuroprotective effects of LY379268, a selective mGlu2/3 receptor agonist: investigations into possible mechanisms of action in vivo. J.Pharmacol.Exp.Ther. 294 800. PMID: 10945827.

Collado et al (2002) (2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-methylcyclopropyl) glycine is a potent and selective metabotropic group 2 agonist with anxiolytic properties. J.Med.Chem. 45 3619. PMID: 12166935.

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Keywords: LY 379268, supplier, selective, group, II, agonists, Group, Receptors, mGlu2, mGluR2, mGlu3, mGluR3, Glutamate, Metabotropic, LY379268

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