R&D Systems Inc. Tocris Bioscience Boston Biochem

Cocaine hydrochloride

Cat. No. 2833

Cocaine hydrochloride C17H21NO4.HCl [53-21-4]

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Chemical Name: 3β-Hydroxy-1αH,5αH-tropane-2β-carboxylic acid methyl ester benzoate hydrochloride

Biological Activity

Competitive inhibitor of monoamine neurotransmitter transporters. Inhibits dopamine (DAT), serotonin (SERT) and noradrenalin (NET) transporters with Ki values are 267, 392 and 872 nM respectively. Psychostimulant.

Technical Data

M.Wt:
339.81
Formula:
C17H21NO4.HCl
Solubility:
Soluble to 100 mM in water
Purity:
>99 %
Storage:
Store at RT
CAS No:
53-21-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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References

Fleckenstein et al (2000) Differential effects of stimulants on monoaminergic transporters: pharmacological consequences and implications for neurotoxicity. Eur.J.Pharmacol. 406 1. PMID: 11011026.

Torres et al (2003) Plasma membrane monoamine transporters: structure, regulation and function. Nat.Rev.Neurosci. 4 13. PMID: 12511858.

If you know of a relevant citation for this product please let us know.

Keywords: Cocaine hydrochloride, supplier, inhibitors, monoamine, transporters, noradrenalin, noradrenaline, transporters, NET, adrenergic, monoamine, neurotransmitter, DAT, dopamine, serotonin, SERT, 5-HT, reuptake, 5-Hydroxytryptamine

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