LY 344864 hydrochlorideCat No. 2451 |
Price and Availability |
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Chemical Name: N-[(3R)-3-(Dimethylamino)-2,3,4,9-tetrahydro-1H-carbazo l-6-yl]-4-fluorobenzamide hydrochloride |
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Biological Activity
Potent, selective 5-HT1F receptor agonist (EC50 = 3 nM). Displays > 80-fold selectivity over other 5-HT receptors (Ki values are 0.006, 0.53, 0.55, 0.56, 1.42, 1.70, 3.50, 3.94 and 4.85 μM for 5-HT1F, 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2B, 5-HT2C, 5-HT2A and 5-HT7 receptors respectively). Inhibits neurogenic dural inflammation in vivo following i.v. and oral administration.Licensing Information
Sold under license from Eli Lilly and Company.Technical Data
M.Wt:The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.
Resources
Certificate of Analysis / MSDS
References
Lee et al (1997) Characterization of LY344864 as a pharmacological tool to study 5-HT1F receptors: binding affinities, brain penetration and activity in the neurogenic dural inflammation model of migraine. Life Science 61 2117. Ramadan et al (2003) 5-HT1F receptor agonists in acute migraine treatment: a hypothesis. Cephalalgia 23 776. Goadsby and Classey (2003) Evidence for serotonin (5-HT)1B, 5-HT1D and 5-HT1F receptor inhibitory effects on trigeminal neurons with craniovascular input. Neuroscience 122 491.If you know of a useful citation for this product please let us know.
Keywords: LY 344864 hydrochloride, Potent, selective, 5-HT1F, agonists, Serotonin, Receptors, LY344864, hydrochloride
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