Valproic acid, sodium salt
Cat No. 2815
Price and Availability
Alternative Name: SodiumValproate
Chemical Name: Sodium 2-propylpentanoate
Biological Activity
Histone deacetylase inhibitor (IC50 = 400 μM) that exhibits anticancer, anti-inflammatory and neuroprotective effects. Displays anticonvulsive activity via an increase in GABA levels and decreases Aβ production in animal models of Alzheimer's disease. Also attenuates NMDA-mediated excitation, blocks voltage-gated Na+ channels and modulates firing of neurons.Technical Data
M.Wt:The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.
Resources
Certificate of Analysis / MSDS
References
Phiel et al (2001) Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen. J.Biol.Chem. 276 36734. Kostrouchova et al (2007) Valproic acid, a molecular lead to multiple regulatory pathways. Folia Biologica 53 37. Kim et al (2007) Histone deacetylase inhibitors exhibit anti-inflammatory and neuroprotective effects in a rat permanent ischemic model of stroke: multiple mechanisms of action. J.Pharmacol.Exp.Ther. 321 892. Qing et al (2008) Valproic acid inhibits Abeta production, neuritic plaque formation, and behavioural defects in Alzheimer's disease mouse models. J.Exp.Med. 205 2781.View Related Products by Target
Keywords: Valproic acid, sodium salt, Histone, deacetylases, inhibitors, Increases, GABA, levels, anticonvulsant, HDAC, GABAA, GABAC, Receptors, GABAB,
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