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Withaferin A

Cat No. 2816

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Chemical Name: (4b,5b,6b,22R)-5,6-Epoxy-4,22,27-trihydroxy-1-oxoergost a-2,24-dien-26-oic acid d-lactone

Biological Activity

Steroid lactone that displays anti-inflammatory, antitumor and antiangiogenic activity. Inhibits endothelial cells (HUVEC) spouting in vitro (IC₅₀ = 12 nM) and in vivo. Prevents NF-κB activation by inhibiting activation of IKKβ. Also inhibits chymotrypsin-like activity of the 20S proteasome.

Technical Data

M.Wt:

470.6

Formula:

C₂₈H₃₈O₆

Solubility:

Soluble in DMSO and in ethanol

Purity:

>98 %

Storage:

Desiccate at -20°C

CAS No:

[5119-48-2]

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.

Resources

Certificate of Analysis / MSDS

Certificate of Analysis: View current batch

Material Safety Data Sheet: View current batch

References

Mohan et al (2004) Withaferin A is a potent inhibitor of angiogenesis. Angiogenesis 7 115. Yang et al (2007) The tumor proteasome is a primary target for the natural anticancer compound withaferin A isolated from "Indian Winter Cherry". Mol.Pharmacol. 71 426. Kaileh et al (2007) Withaferin A strongly elicits IkB kinase b hyperphosphorylation concomitant with potent inhibition of its kinase activity. J.Biol.Chem. 282 4253.

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Keywords: Withaferin A, inhibitors, NF-κB, NF-kappaB, NF-kB, activation, Nuclear, Factor, Kappa, B, Cytokine, Signaling, Signalling, Transcription, Factors, WithaferinA