Cat. No. 2836
Alternative Name: AA-5-HT
Chemical Name: N-[2-(5-Hydroxy-1H-indol-3-yl)ethyl
Biological ActivityDual fatty acid amide hydrolase (FAAH) inhibitor/TRPV1 antagonist (IC50 values are 5.6 μM and 37 - 40 nM for FAAH and TRPV1 respectively). Inactive at cPLA2, CB1 or 5-HT receptors. Displays strong analgesic activity against both acute and chronic peripheral pain.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Bisogno et al (1998) Arachidonoylserotonin and other novel inhibitors of fatty acid amide hydrolase. Biochem.Biophys.Res.Comms. 248 515.
Di Marzo et al (2004) The endocannabinoid system and its therapeutic exploitation. Nat.Rev.Drug Discov. 3 771. PMID: 15340387.
Maione et al (2007) Analgesic actions of N-arachidonoyl-serotonin, a fatty acid amide hydrolase inhibitor with antagonistic activity at vanilloid TRPV1 receptors. Br.J.Pharmacol. 150 766. PMID: 17279090.
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Keywords: Arachidonyl serotonin, supplier, Dual, FAAH, inhibitors, TRPV1, antagonists, cannabinoids, Receptors, Vanillioid, VR1, Channels, Transient, Receptor, Potential, Anandamide, Amidase, Fatty, Acid, Amide, Hydrolases, AA5HT
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