PP 3

Cat. No. 2794

PP 3 C11H9N5 [5334-30-5]

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Chemical Name: 1-Phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Biological Activity

Negative control for the Src kinase inhibitor PP 2 (Cat. No. 1407). Inhibits EGFR kinase (IC50 = 2.7 μM).

Technical Data

Soluble to 100 mM in DMSO and to 25 mM in ethanol
>98 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Traxler et al (1997) Use of a pharmacophore model for the design of EGF-R tyrosine kinase inhibitors: 4-(phenylamino)pyrazolo[3,4-d]pyrimidines. J.Med.Chem. 40 3601. PMID: 9357527.

Hou et al (2007) PP2, a potent inhibitor of Src family kinases, protects against hippocampal CA1 pyramidal cell death after transient global brain ischemia. Neurosci.Letts. 420 235.

If you know of a relevant citation for this product please let us know.

View Related Products by Product Action

Keywords: PP 3, supplier, Negative, control, PP, 2, EGFR-kinases, inhibitors, Src, negative, Epidermal, Growth, Factors, Receptors, ErbB, Her, EGFR, Receptor, Tyrosine, RTKs, PP3, EGFR Inhibitors

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