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PP 3

Cat. No. 2794

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Chemical Name: 1-Phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Biological Activity

Negative control for the Src kinase inhibitor PP 2 (Cat. No. 1407). Inhibits EGFR kinase (IC₅₀ = 2.7 μM).

Technical Data

M.Wt:

211.22

Formula:

C₁₁H₉N₅

Solubility:

Soluble to 100 mM in DMSO and to 25 mM in ethanol

Purity:

>98 %

Storage:

Store at -20°C

CAS No:

5334-30-5

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Traxler et al (1997) Use of a pharmacophore model for the design of EGF-R tyrosine kinase inhibitors: 4-(phenylamino)pyrazolo[3,4-d]pyrimidines. J.Med.Chem. 40 3601. PMID: 9357527.

Hou et al (2007) PP2, a potent inhibitor of Src family kinases, protects against hippocampal CA1 pyramidal cell death after transient global brain ischemia. Neurosci.Letts. 420 235.

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