Home » Pharmacology » Enzymes » Proteases » Calpains » Acetyl-Calpastatin (184-210) (human)

Acetyl-Calpastatin (184-210) (human)

Cat. No. 2950

Price and Availability

For Acetyl-Calpastatin (184-210) (human) pricing & availability please select your country from the drop down menu:
Submit

By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Biological Activity

Selective calpain inhibitor. Strongly inhibits calpain I (K_i = 0.2 nM) and II but does not inhibit papain, trypsin and cathepsin L (K_i = 6 μM). Increases secretion of amyoid β-protein (Aβ) 42, Aβ40 and Aβ42 ratio.

Technical Data

M.Wt:

3177.65

Formula:

C₁₄₂H₂₃₀N₃₆O₄₄S

Sequence:

DPMSSTYIEELGKREVTIPPKYRELLA

(Modifications: Asp-1 = N-terminal Ac, Ala-27 = C-terminal amide)

Solubility:

Soluble to 5 mg/ml in water

Storage:

Desiccate at -20°C

CAS No:

123714-50-1

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch

Safety Data Sheet: View Safety Data Sheet

References

Maki et al (1989) Inhibition of calapin by a synthetic oligopeptide corresponding to an exon of the human calpastatin gene. J.Biol.Chem. 264 18866. PMID: 2553724.

Yamazaki et al (1997) Specific increase in amyloid β-protein 42 secretion ratio by calpain inhibition. Biochem. 36 8377.

Fiorino et al (2007) A new cell-permeable calpain inhibitor. J.Peptide Sci. 13 70.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Calcium Signaling Calcium-Sensitive Protease Modulators

Calpains Proteases

Keywords: Acetyl-calpastatin 184-210 (human), supplier, Selective, calpain, inhibitors, Ca2+Sensitive, Protease, modulators, Calcium-Sensitive, Ca2+, Signaling, Signalling, Proteinases, Proteases, Acetyl-calpastatin184-210, (human)

Quick Order

Find multiple products by catalog number

Calcium Imbalance and Neuroprotective Targets

Written by E. Besancon et al

'Calcium Imbalance and Neuro-protective Targets in Cerebral Ischemia & Brain Injury' highlights the key targets involved in stroke, trauma and neurodegeneration.