R&D Systems Inc. Tocris Bioscience Boston Biochem

Acetyl-Calpastatin (184-210) (human)

Cat. No. 2950

Acetyl-calpastatin 184-210 (human) Ac-Asp-Pro-Met-Ser-Ser-Thr-Tyr-Ile-Glu-Glu-Leu-Gly-Lys-Arg-Glu-Val-Thr-Ile-Pro-Pro-Lys-Tyr-Arg-Glu-Leu-Leu-Ala-NH2

Price and Availability

For Acetyl-Calpastatin (184-210) (human) pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Biological Activity

Selective calpain inhibitor. Strongly inhibits calpain I (Ki = 0.2 nM) and II but does not inhibit papain, trypsin and cathepsin L (Ki = 6 μM). Increases secretion of amyoid β-protein (Aβ) 42, Aβ40 and Aβ42 ratio.

Technical Data

M.Wt:
3177.65
Formula:
C142H230N36O44S
Sequence:
DPMSSTYIEELGKREVTIPPKYRELLA

(Modifications: Asp-1 = N-terminal Ac, Ala-27 = C-terminal amide)

Solubility:
Soluble to 5 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
123714-50-1

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

References

Maki et al (1989) Inhibition of calapin by a synthetic oligopeptide corresponding to an exon of the human calpastatin gene. J.Biol.Chem. 264 18866. PMID: 2553724.

Yamazaki et al (1997) Specific increase in amyloid β-protein 42 secretion ratio by calpain inhibition. Biochem. 36 8377.

Fiorino et al (2007) A new cell-permeable calpain inhibitor. J.Peptide Sci. 13 70.

If you know of a relevant citation for this product please let us know.

Keywords: Acetyl-calpastatin 184-210 (human), supplier, Selective, calpain, inhibitors, Ca2+Sensitive, Protease, modulators, Calcium-Sensitive, Ca2+, Signaling, Signalling, Proteinases, Proteases, Acetyl-calpastatin184-210, (human)

Quick Order

Find multiple products by catalog number

divider line

Calcium Imbalance and Neuroprotective Targets

Written by E. Besancon et al

Neuroprotection Poster

'Calcium Imbalance and Neuro-protective Targets in Cerebral Ischemia & Brain Injury' highlights the key targets involved in stroke, trauma and neurodegeneration.

divider line

New Product Guide

NPG

Highlights over 130 new products added in the second half of 2013. Request a copy or view PDF today.

divider line

New Products in this Area

Ramipril

Non-peptide, competitive angiotensin converting enzyme (ACE) inhibitor

Aprotinin

Competitive serine protease inhibitor

TCID

Selective ubiquitin C-terminal hydrolase-L3 (UCH-L3) inhibitor

2-MPPA

Selective glutamate carboxypeptidase II (GCP II) inhibitor; orally bioavailable

E 64

Potent and irreversible cysteine protease inhibitor

AEBSF

Broad spectrum, irreversible inhibitor of serine proteases

TC-E 5006

γ-secretase modulator; reduces Aβ42 levels

PTIQ

Potent MMP-3 expression inhibitor; neuroprotective

Sign-up for new product e-alerts
divider line

Twitter Updates

Follow @Tocris on Twitter

Follow us on Twitter!

Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.