Acetyl-Calpastatin (184-210) (human)

Cat. No. 2950

Acetyl-calpastatin 184-210 (human) Ac-Asp-Pro-Met-Ser-Ser-Thr-Tyr-Ile-Glu-Glu-Leu-Gly-Lys-Arg-Glu-Val-Thr-Ile-Pro-Pro-Lys-Tyr-Arg-Glu-Leu-Leu-Ala-NH2

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Biological Activity

Selective calpain inhibitor. Strongly inhibits calpain I (Ki = 0.2 nM) and II but does not inhibit papain, trypsin and cathepsin L (Ki = 6 μM). Increases secretion of amyoid β-protein (Aβ) 42, Aβ40 and Aβ42 ratio.

Technical Data


(Modifications: Asp-1 = N-terminal Ac, Ala-27 = C-terminal amide)

Soluble to 5 mg/ml in water
Desiccate at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet


Maki et al (1989) Inhibition of calapin by a synthetic oligopeptide corresponding to an exon of the human calpastatin gene. J.Biol.Chem. 264 18866. PMID: 2553724.

Yamazaki et al (1997) Specific increase in amyloid β-protein 42 secretion ratio by calpain inhibition. Biochem. 36 8377.

Fiorino et al (2007) A new cell-permeable calpain inhibitor. J.Peptide Sci. 13 70.

If you know of a relevant citation for this product please let us know.

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