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BAPTA AM

Cat No. 2787

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Chemical Name: 1,2-Bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid tetrakis(acetoxymethyl ester)

Biological Activity

Selective calcium chelator that is the cell-permeable analog of BAPTA (Cat No. 2786). Blocks hK_v1.5, hERG and hK_v1.3 channels (K_i values are 1.23, 1.30 and 1.45 μM respectively). Displays antithrombotic activity in vitro.

Technical Data

M.Wt:

764.68

Formula:

C₃₄H₄₀N₂O₁₈

Solubility:

Soluble to 30 mM in DMSO

Purity:

>95 %

Storage:

Store at -20°C

CAS No:

[126150-97-8]

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis and MSDS.

Resources

Certificate of Analysis / MSDS

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Material Safety Data Sheet: View current batch

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References

Raspe et al (1989) Enhanced release of prostacyclin from quin 2-loaded endothelial cells. Eur.J.Pharmacol. 163 345. Heilporn et al (1994) Synthesis of BAPTA-AM analogues capable of enhancing the vascuar production of prostacyclin. Bull.Soc.Chim.Belg. 103 309. Tang et al (2007) The membrane permeable calcium chelaotr BAPTA-AM directly blocks human ether a-go-go-related gene potassium channels stably expressed in HEK 293 cells. Biochem.Pharmacol. 74 1596.

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Calcium Signaling General Calcium Signaling Agents Potassium Channels

Reagents Voltage-gated Potassium (K_V) Channels

Keywords: BAPTA AM, Cell-permeable, Ca2+, chelator, hERG, hKv13, hKv15, channels, blockers, Calcium, Signaling, Signalling, Agents, General, Potassium, KV, Channels, voltage-gated, voltage-dependent, K+, BAPTAAM