Stattic

Cat. No. 2798

Stattic C8H5NO4S [19983-44-9]

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Chemical Name: 6-Nitrobenzo[b]thiophene 1,1-dioxide

Biological Activity

Small molecule inhibitor of STAT3. Inhibits binding of tyrosine-phosphorylated peptide motifs to STAT3 SH2 domain and inhibits STAT3 activation, dimerization and nuclear translocation. Displays selectivity over STAT1, STAT5, c-Myc/Max, Jun/Jun and Lck. Induces apoptosis in STAT3-dependent cancer cell lines.

Technical Data

M.Wt:
211.19
Formula:
C8H5NO4S
Solubility:
Soluble to 50 mM in DMSO and to 5 mM in ethanol
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
19983-44-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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References

Schust et al (2006) Stattic: a small-molecule inhibitor of STAT3 activation and dimerization. Chem.Biol. 13 1235. PMID: 17114005.

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Keywords: Stattic, supplier, Selective, STAT3, inhibitors, STAT, Transcription, Factors, Signal, Transducers, activators, Cytokine, NF-κB, NF-kappaB, Signaling, Signalling, Tocris Bioscience, STAT Inhibitors

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