R&D Systems Inc. Tocris Bioscience Boston Biochem

Stattic

Cat. No. 2798

Stattic C8H5NO4S [19983-44-9]

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Chemical Name: 6-Nitrobenzo[b]thiophene 1,1-dioxide

Biological Activity

Small molecule inhibitor of STAT3. Inhibits binding of tyrosine-phosphorylated peptide motifs to STAT3 SH2 domain and inhibits STAT3 activation, dimerization and nuclear translocation. Displays selectivity over STAT1, STAT5, c-Myc/Max, Jun/Jun and Lck. Induces apoptosis in STAT3-dependent cancer cell lines.

Technical Data

M.Wt:
211.19
Formula:
C8H5NO4S
Solubility:
Soluble to 50 mM in DMSO and to 5 mM in ethanol
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
19983-44-9

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Certificate of Analysis / Safety Data Sheet

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References

Schust et al (2006) Stattic: a small-molecule inhibitor of STAT3 activation and dimerization. Chem.Biol. 13 1235. PMID: 17114005.

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View Related Products by Target

Keywords: Stattic, supplier, Selective, STAT3, inhibitors, STAT, Transcription, Factors, Signal, Transducers, activators, Cytokine, NF-κB, NF-kappaB, Signaling, Signalling

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