Stattic

Cat. No. 2798

Stattic C8H5NO4S [19983-44-9]

Price and Availability

For Stattic pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: 6-Nitrobenzo[b]thiophene 1,1-dioxide

Biological Activity

Small molecule inhibitor of STAT3. Inhibits binding of tyrosine-phosphorylated peptide motifs to STAT3 SH2 domain and inhibits STAT3 activation, dimerization and nuclear translocation. Displays selectivity over STAT1, STAT5, c-Myc/Max, Jun/Jun and Lck. Induces apoptosis in STAT3-dependent cancer cell lines.

Technical Data

M.Wt:
211.19
Formula:
C8H5NO4S
Solubility:
Soluble to 50 mM in DMSO and to 5 mM in ethanol
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
19983-44-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Select another batch:
Safety Data Sheet: View Safety Data Sheet

References

Schust et al (2006) Stattic: a small-molecule inhibitor of STAT3 activation and dimerization. Chem.Biol. 13 1235. PMID: 17114005.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: Stattic, supplier, Selective, STAT3, inhibitors, STAT, Transcription, Factors, Signal, Transducers, activators, Cytokine, NF-κB, NF-kappaB, Signaling, Signalling

Quick Order

Find multiple products by catalog number

divider line

Cancer Research Product Guide

Cancer Research Guide

Highlights over 350 products for cancer research. Request a copy or view PDF today.

divider line

Immunology Guide

Immunology Product Listing

Highlights over 190 products for immunology research. Request a copy or view PDF today.

divider line

New Product Guide

NPG

Highlights 130 new products added in the first half of 2015. View PDF today.

divider line

New Products in this Area

C 87

TNF-α inhibitor

JTE 607 dihydrochloride

Cytokine release inhibitor; anti-inflammatory

CRID3 sodium salt

Potent NLRP3 inflammasome inhibitor; inhibits IL-1β production

Sign-up for new product e-alerts
divider line

Twitter Updates

Follow @Tocris on Twitter

Follow us on Twitter!

Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.