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Stattic

Cat. No. 2798

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Chemical Name: 6-Nitrobenzo[b]thiophene 1,1-dioxide

Biological Activity

Small molecule inhibitor of STAT3. Inhibits binding of tyrosine-phosphorylated peptide motifs to STAT3 SH2 domain and inhibits STAT3 activation, dimerization and nuclear translocation. Displays selectivity over STAT1, STAT5, c-Myc/Max, Jun/Jun and Lck. Induces apoptosis in STAT3-dependent cancer cell lines.

Technical Data

M.Wt:

211.19

Formula:

C₈H₅NO₄S

Solubility:

Soluble to 50 mM in DMSO and to 5 mM in ethanol

Purity:

>99 %

Storage:

Store at +4°C

CAS No:

19983-44-9

The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.

Resources

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

References

Schust et al (2006) Stattic: a small-molecule inhibitor of STAT3 activation and dimerization. Chem.Biol. 13 1235. PMID: 17114005.

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