M617

Cat. No. 2697

M617 Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-Gln-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-NH2

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Alternative Name: Galanin(1-13)-Gln14-bradykinin(2-9)amide

Biological Activity

Selective galanin GAL1 receptor agonist (Ki values are 0.23 and 5.71 nM for GAL1 and GAL2 receptors respectively). Enhances food consumption in rats following i.c.v. administration and reduces CAP-induced inflammatory pain.

Technical Data

M.Wt:
2361.68
Formula:
C112H161N29O28
Sequence:
GWTLNSAGYLLGPQPPGFSPFR

(Modifications: Arg-22 = C-terminal amide)

Solubility:
Soluble to 1 mg/ml in water
Storage:
Store at -20°C
CAS No:
860790-38-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

References

Lundstrom et al (2005) A galanin receptor subtype 1 specific agonist. Int.J.Pept.Res.Ther. 11 17.

Jimenez-Andrade et al (2006) Activation of peripheral galanin receptors: differential effects on nociception. Pharmacol.Biochem.Behav. 85 273. PMID: 16996122.

Mazarati et al (2006) Regulation of kindling epileptogenesis by hippocampal galanin type 1 and type 2 receptors: the effects of subtype-selective agonists and the role of G-protein-mediated signaling. J.Pharmacol.Exp.Ther. 318 700. PMID: 16699066.

If you know of a relevant citation for this product please let us know.

View Related Products by Target

Keywords: M617, supplier, Selective, GAL1, GalR1, agonists, Receptors, Galanin

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