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KF 38789Cat. No. 2748 |
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Chemical Name: 3-[7-(2,4-Dimethoxyphenyl)-2,3,6,7-tetrahydro-1,4-thiazepin-5-yl]-4-hydroxy-6-methyl-2H-pyran-2-one |
Biological Activity
Selective inhibitor of P-selectin-mediated cell adhesion (IC50 = 1.97 μM) that displays no effects on L-selectin- and E-selectin-mediated adhesion. Blocks P-selectin-mediated binding in vitro and leukocyte accumulation in vivo.Certificate of Analysis / Safety Data Sheet
References
Haggerty et al (2000) Dissecting cellular processes using small molecules: identification of colchicine-like, taxol-like and other small moleculaes that perturb mitosis. Chem.Biol. 7 275. PMID: 10780927.
Ohta et al (2001) Inhibition of P-selectin specific cell adhesion by a low molecular weight, non-carbohydrate compound, KF38779. Inflamm.Res. 50 544. PMID: 11766994.
Kaila et al (2007) Synthesis and biological evaluation of quinoline salicylic acids as P-selectin antagonists. J.Med.Chem. 50 21. PMID: 17201408.
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Keywords: KF 38789, supplier, Selective, inhibitors, P-selectin-mediated, cell, adhesio, Adhesion, Molecules, KF38789
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